(1R,2S,5R)-2-tert-butyl-5-metylcyclohexyl glyoxylate

Base Information

• Chemical Name: (1R,2S,5R)-2-tert-butyl-5-metylcyclohexyl glyoxylate
• CAS No.: 104264-93-9
• Molecular Formula: C₁₃H₂₂O₃
• Molecular Weight: 226.316
• Mol file: 104264-93-9.mol

Synonyms:

Chemical Property of (1R,2S,5R)-2-tert-butyl-5-metylcyclohexyl glyoxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,5R)-2-tert-butyl-5-metylcyclohexyl glyoxylate

There total 5 articles about (1R,2S,5R)-2-tert-butyl-5-metylcyclohexyl glyoxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(1R,2S,5R)-2-tert-butyl-5-methylcyclohexyl (nitrooxy)acetate (104197-82-2) → (1R,2S,5R)-2-tert-butyl-5-metylcyclohexyl glyoxylate (104264-93-9)

Guidance literature:

With sodium acetate; dimethyl sulfoxide; for 1h; Ambient temperature;

DOI:10.1021/jo00375a006

Reference yield:

(2S,5R)-2-(tert-butyl)-5-methylcyclohexan-1-one (56782-80-0) → (1R,2S,5R)-2-tert-butyl-5-metylcyclohexyl glyoxylate (104264-93-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 61 percent / Na, isopropanol / toluene / 12 h / Ambient temperature

2: p-toluenesulfonic acid monohydrate / benzene / 24 h / Heating

3: AgNO₃ / acetonitrile / 48 h / Ambient temperature

4: 74 percent / sodium acetate trihydrate, DMSO / 1 h / Ambient temperature

With sodium acetate; sodium; toluene-4-sulfonic acid; silver nitrate; dimethyl sulfoxide; isopropyl alcohol; In toluene; acetonitrile; benzene;

DOI:10.1021/jo00375a006

Reference yield:

(1R,2S,5R)-2-dimethylethyl-5-methyl-cyclohexan-1-ol (75419-02-2) → (1R,2S,5R)-2-tert-butyl-5-metylcyclohexyl glyoxylate (104264-93-9)

Guidance literature:

Multi-step reaction with 3 steps

1: p-toluenesulfonic acid monohydrate / benzene / 24 h / Heating

2: AgNO₃ / acetonitrile / 48 h / Ambient temperature

3: 74 percent / sodium acetate trihydrate, DMSO / 1 h / Ambient temperature

With sodium acetate; toluene-4-sulfonic acid; silver nitrate; dimethyl sulfoxide; In acetonitrile; benzene;

DOI:10.1021/jo00375a006

upstream raw materials:

(1R,2S,5R)-2-tert-butyl-5-methylcyclohexyl (nitrooxy)acetate

(1R,2S,5R)-2-dimethylethyl-5-methyl-cyclohexan-1-ol

(2S,5R)-2-(tert-butyl)-5-methylcyclohexan-1-one

pulegone

Downstream raw materials:

(1R,2S,5R)-2-tert-butyl-5-methylcyclohexyl (2R)-2-hydroxy-4(E)-octenoate

(1R,2S,5R)-2-tert-butyl-5-methylcyclohexyl (2S)-2-hydroxy-4(E)-octenoate

(S)-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-hydroxy-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester