(S)-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-hydroxy-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

• Chemical Name: (S)-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-hydroxy-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
• CAS No.: 153809-46-2
• Molecular Formula: C₂₄H₄₀O₄Si
• Molecular Weight: 420.665
• Mol file: 153809-46-2.mol

Synonyms:(S)-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-hydroxy-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Chemical Property of (S)-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-hydroxy-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-hydroxy-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

There total 1 articles about (S)-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-hydroxy-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyldimethyl(phenoxy)silane (18052-27-2) + (1R,2S,5R)-2-tert-butyl-5-metylcyclohexyl glyoxylate (104264-93-9) → (S)-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-hydroxy-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (153809-46-2) + (R)-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-hydroxy-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:

With tin(IV) chloride; In dichloromethane; at -30 - -3 ℃; Product distribution; multisteps; var. reagents;

DOI:10.1016/S0957-4166(00)82212-0

Reference yield: 100.0%

(S)-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-hydroxy-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (153809-46-2) → (S)-Hydroxy-(4-hydroxy-phenyl)-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/S0957-4166(00)82212-0

Reference yield:

(S)-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-hydroxy-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (153809-46-2) → (S)-α,4-dihydroxy-benzeneacetic acid (13244-75-2)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; Ambient temperature;

DOI:10.1016/S0957-4166(00)82212-0

upstream raw materials:

tert-butyldimethyl(phenoxy)silane

(1R,2S,5R)-2-tert-butyl-5-metylcyclohexyl glyoxylate

Downstream raw materials:

(S)-α,4-dihydroxy-benzeneacetic acid