Technology Process of 3,5-di-iodo-4'-O-methyl-3'-<(6-oxo-1,6-dihydropyridazin-3-yl)methyl>-N-trifluoroacetyl-L-thyronine ethyl ester
There total 8 articles about 3,5-di-iodo-4'-O-methyl-3'-<(6-oxo-1,6-dihydropyridazin-3-yl)methyl>-N-trifluoroacetyl-L-thyronine ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 81 percent / phosphorus tribromide / CH2Cl2 / -5 °C
2: 87 percent / sodium cyanide / dimethylsulfoxide
3: 64 percent / sodium hydride / dimethylformamide / 2 h
4: 82 percent / hydrochloric acid / acetic acid; H2O / 6 h / Heating
5: 36 percent / methanesulphonyl chloride / pyridine / 1.17 h / Heating
6: H2 / 10percent Pd/C / acetic acid / 1 h / 2585.7 Torr
7: 1.) sulphuric acid, sodium nitrite, 2.) potassium iodide,iodine, urea / 1.) water, -10 deg C, 2.) chloroform, water, RT, 1-2 h
With
hydrogenchloride; sodium cyanide; sulfuric acid; hydrogen; iodine; phosphorus tribromide; sodium hydride; methanesulfonyl chloride; urea; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
pyridine; dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1039/P19880003085
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 95 percent / sodium borohydride / methanol
2: 81 percent / phosphorus tribromide / CH2Cl2 / -5 °C
3: 87 percent / sodium cyanide / dimethylsulfoxide
4: 64 percent / sodium hydride / dimethylformamide / 2 h
5: 82 percent / hydrochloric acid / acetic acid; H2O / 6 h / Heating
6: 36 percent / methanesulphonyl chloride / pyridine / 1.17 h / Heating
7: H2 / 10percent Pd/C / acetic acid / 1 h / 2585.7 Torr
8: 1.) sulphuric acid, sodium nitrite, 2.) potassium iodide,iodine, urea / 1.) water, -10 deg C, 2.) chloroform, water, RT, 1-2 h
With
hydrogenchloride; sodium cyanide; sodium tetrahydroborate; sulfuric acid; hydrogen; iodine; phosphorus tribromide; sodium hydride; methanesulfonyl chloride; urea; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
pyridine; methanol; dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1039/P19880003085
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 87 percent / sodium cyanide / dimethylsulfoxide
2: 64 percent / sodium hydride / dimethylformamide / 2 h
3: 82 percent / hydrochloric acid / acetic acid; H2O / 6 h / Heating
4: 36 percent / methanesulphonyl chloride / pyridine / 1.17 h / Heating
5: H2 / 10percent Pd/C / acetic acid / 1 h / 2585.7 Torr
6: 1.) sulphuric acid, sodium nitrite, 2.) potassium iodide,iodine, urea / 1.) water, -10 deg C, 2.) chloroform, water, RT, 1-2 h
With
hydrogenchloride; sodium cyanide; sulfuric acid; hydrogen; iodine; sodium hydride; methanesulfonyl chloride; urea; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
pyridine; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1039/P19880003085
