(1S)-<1-²H> N-t-butyloxycarbonyl 4-methoxybenzylamine

Base Information

Chemical Name:(1S)-<1-²H> N-t-butyloxycarbonyl 4-methoxybenzylamine
CAS No.:118063-60-8
Molecular Formula:C₁₃H₁₉NO₃
Molecular Weight:238.291
Hs Code.:

(1S)-<1-<sup>2</sup>H> N-t-butyloxycarbonyl 4-methoxybenzylamine

Synonyms:

Suppliers and Price of (1S)-<1-²H> N-t-butyloxycarbonyl 4-methoxybenzylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S)-<1-²H> N-t-butyloxycarbonyl 4-methoxybenzylamine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
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Technology Process of (1S)-<1-²H> N-t-butyloxycarbonyl 4-methoxybenzylamine

There total 6 articles about (1S)-<1-²H> N-t-butyloxycarbonyl 4-methoxybenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39508-36-6
1-<²H>-1-(4-methoxyphenyl)-1-morpholinoacetonitrile

: 118063-60-8
(1S)-<1-²H> N-t-butyloxycarbonyl 4-methoxybenzylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 86.3 percent / 2N HCl / H₂O / 2 h / Heating

2: 75 percent / S-(-)-B-isopinocampheyl-9-borabicyclo<3.3.1>nonane / tetrahydrofuran / 25 degC, 4 h then 75 degC, 1 h

3: 73 percent / triphenylphosphine, diethylazidocarboxylate / tetrahydrofuran / 0 degC, 4 h then 25 degC, 18 h

4: 1.) sodium borohydride, acetic acid / 1.) 2-propanol/water, 25 degC, 24 h then 80 degC, 2 h; 2.) dioxane/water, pH=8.5, 0 degC, 4 h then 25 degC, 18 h

With hydrogenchloride; sodium tetrahydroborate; S-(-)-B-isopinocampheyl-9-borabicyclo<3.3.1>nonane; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; water;
DOI:10.1016/S0040-4020(01)86064-6

Reference yield:

: 19486-71-6
p-methoxybenzaldehyde-d1

: 118063-60-8
(1S)-<1-²H> N-t-butyloxycarbonyl 4-methoxybenzylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / S-(-)-B-isopinocampheyl-9-borabicyclo<3.3.1>nonane / tetrahydrofuran / 25 degC, 4 h then 75 degC, 1 h

2: 73 percent / triphenylphosphine, diethylazidocarboxylate / tetrahydrofuran / 0 degC, 4 h then 25 degC, 18 h

3: 1.) sodium borohydride, acetic acid / 1.) 2-propanol/water, 25 degC, 24 h then 80 degC, 2 h; 2.) dioxane/water, pH=8.5, 0 degC, 4 h then 25 degC, 18 h

With sodium tetrahydroborate; S-(-)-B-isopinocampheyl-9-borabicyclo<3.3.1>nonane; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)86064-6

Reference yield:

: 15190-13-3
(4-methoxy-phenyl)-morpholin-4-yl-acetonitrile

: 118063-60-8
(1S)-<1-²H> N-t-butyloxycarbonyl 4-methoxybenzylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / NaH, ⁽²⁾H₂O / tetrahydrofuran / 50 degC, 2 h then 0 degC, 10 min

2: 86.3 percent / 2N HCl / H₂O / 2 h / Heating

3: 75 percent / S-(-)-B-isopinocampheyl-9-borabicyclo<3.3.1>nonane / tetrahydrofuran / 25 degC, 4 h then 75 degC, 1 h

4: 73 percent / triphenylphosphine, diethylazidocarboxylate / tetrahydrofuran / 0 degC, 4 h then 25 degC, 18 h

5: 1.) sodium borohydride, acetic acid / 1.) 2-propanol/water, 25 degC, 24 h then 80 degC, 2 h; 2.) dioxane/water, pH=8.5, 0 degC, 4 h then 25 degC, 18 h

With hydrogenchloride; sodium tetrahydroborate; S-(-)-B-isopinocampheyl-9-borabicyclo<3.3.1>nonane; water; sodium hydride; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; water;
DOI:10.1016/S0040-4020(01)86064-6