(2,5-DIFLUORO-PHENYL)-ACETALDEHYDE

Base Information

• Chemical Name: (2,5-DIFLUORO-PHENYL)-ACETALDEHYDE
• CAS No.: 109346-82-9
• Molecular Formula: C₈H₆F₂O
• Molecular Weight: 156.132
• Mol file: 109346-82-9.mol

Synonyms:

Chemical Property of (2,5-DIFLUORO-PHENYL)-ACETALDEHYDE

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-(2,5-Difluorophenyl)acetaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2,5-DIFLUORO-PHENYL)-ACETALDEHYDE

There total 3 articles about (2,5-DIFLUORO-PHENYL)-ACETALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2,5-difluorophenyl)ethanol (862255-56-9) → 2-(2,5-difluorophenyl)acetaldehyde (109346-82-9)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In acetonitrile; for 1h; Reflux;

Reference yield:

ethyl 2-(2,5-difluorophenyl)acetate (662138-60-5) → 2-(2,5-difluorophenyl)acetaldehyde (109346-82-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 0.5 h / 20 °C

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 1 h / Reflux

With sodium tetrahydroborate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethanol; acetonitrile;

Reference yield:

2,5-difluorophenylacetic acid (85068-27-5) → 2-(2,5-difluorophenyl)acetaldehyde (109346-82-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / Reflux

2: sodium tetrahydroborate / ethanol / 0.5 h / 20 °C

3: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 1 h / Reflux

With sodium tetrahydroborate; sulfuric acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethanol; acetonitrile;

upstream raw materials:

ethyl 2-(2,5-difluorophenyl)acetate

2,5-difluorophenylacetic acid

2-(2,5-difluorophenyl)ethanol