H-(S)-β²hHis(Tr)-OH

Base Information

Chemical Name:H-(S)-β²hHis(Tr)-OH
CAS No.:847153-59-7
Molecular Formula:C₂₆H₂₅N₃O₂
Molecular Weight:411.503
Hs Code.:

Synonyms:

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Chemical Property of H-(S)-β²hHis(Tr)-OH

Chemical Property:

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Technology Process of H-(S)-β²hHis(Tr)-OH

There total 11 articles about H-(S)-β²hHis(Tr)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 847153-58-6
(S)-benzyl 2-(azidomethyl)-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoate

: 847153-59-7
H-(S)-β²hHis(Tr)-OH

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 2h;
DOI:10.1002/hlca.200490280

Reference yield:

: 53958-93-3
3-(4-imidazolyl)propionic acid monohydrochloride

: 847153-59-7
H-(S)-β²hHis(Tr)-OH

Guidance literature:: Multi-step reaction with 9 steps

1.1: 7.87 g / HCl / 2 h / Heating

2.1: 15.9 g / Et₃N / dimethylformamide / 72 h / 20 °C

3.1: 10.1 g / LiOH*H₂O / tetrahydrofuran; H₂O / 15 h / 20 °C

4.1: Et₃N / tetrahydrofuran / 1.17 h / -30 °C

5.1: BuLi / tetrahydrofuran / 0 °C

5.2: 14.1 g / tetrahydrofuran / 15 h / 0 - 20 °C

6.1: TiCl₄; Et₃N / CH₂Cl₂ / 0.5 h / -10 °C

6.2: 70 percent / TiCl₄ / CH₂Cl₂ / 3 h / -30 - 0 °C

7.1: BuLi / tetrahydrofuran; hexane / 0.17 h / -10 °C

7.2: 70 percent / tetrahydrofuran; hexane / -78 - -20 °C

8.1: 83 percent / HN₃; diisopropyl azodicarboxylate; PPh₃ / benzene / 0.83 h / 20 °C

9.1: 1.26 g / H₂ / Pd/C / ethanol / 2 h

With hydrogenchloride; lithium hydroxide; n-butyllithium; tris-(2-chloro-ethyl)-amine; di-isopropyl azodicarboxylate; hydrogen; titanium tetrachloride; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; benzene; 8.1: Mitsunobu reaction;
DOI:10.1002/hlca.200490280

Reference yield:

: 76-83-5
trityl chloride

: 847153-59-7
H-(S)-β²hHis(Tr)-OH

Guidance literature:: Multi-step reaction with 8 steps

1.1: 15.9 g / Et₃N / dimethylformamide / 72 h / 20 °C

2.1: 10.1 g / LiOH*H₂O / tetrahydrofuran; H₂O / 15 h / 20 °C

3.1: Et₃N / tetrahydrofuran / 1.17 h / -30 °C

4.1: BuLi / tetrahydrofuran / 0 °C

4.2: 14.1 g / tetrahydrofuran / 15 h / 0 - 20 °C

5.1: TiCl₄; Et₃N / CH₂Cl₂ / 0.5 h / -10 °C

5.2: 70 percent / TiCl₄ / CH₂Cl₂ / 3 h / -30 - 0 °C

6.1: BuLi / tetrahydrofuran; hexane / 0.17 h / -10 °C

6.2: 70 percent / tetrahydrofuran; hexane / -78 - -20 °C

7.1: 83 percent / HN₃; diisopropyl azodicarboxylate; PPh₃ / benzene / 0.83 h / 20 °C

8.1: 1.26 g / H₂ / Pd/C / ethanol / 2 h

With lithium hydroxide; n-butyllithium; tris-(2-chloro-ethyl)-amine; di-isopropyl azodicarboxylate; hydrogen; titanium tetrachloride; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; benzene; 7.1: Mitsunobu reaction;
DOI:10.1002/hlca.200490280