Acetic acid (2S,3R,4R,5S,6R)-4-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-4,5-diacetoxy-3-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-tetrahydro-pyran-2-yl ester

Base Information

• Chemical Name: Acetic acid (2S,3R,4R,5S,6R)-4-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-4,5-diacetoxy-3-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-tetrahydro-pyran-2-yl ester
• CAS No.: 120567-17-1
• Molecular Formula: C₅₄H₅₅NO₁₅
• Molecular Weight: 958.028

Synonyms:

Chemical Property of Acetic acid (2S,3R,4R,5S,6R)-4-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-4,5-diacetoxy-3-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-tetrahydro-pyran-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (2S,3R,4R,5S,6R)-4-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-4,5-diacetoxy-3-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-tetrahydro-pyran-2-yl ester

There total 11 articles about Acetic acid (2S,3R,4R,5S,6R)-4-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-4,5-diacetoxy-3-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-tetrahydro-pyran-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) → Acetic acid (2S,3R,4R,5S,6R)-4-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-4,5-diacetoxy-3-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-tetrahydro-pyran-2-yl ester (120567-17-1)

Guidance literature:

Multi-step reaction with 5 steps

1: Ag₂O, KI / dimethylformamide

2: trifluoroacetic acid, H₂O, tetrahydrofuran

3: dimethylaminopropylamine / pyridine

4: PdCl₂/NaOAc / aq. acetic acid

With tetrahydrofuran; water; sodium acetate; 1-amino-3-(dimethylamino)propane; trifluoroacetic acid; potassium iodide; palladium dichloride; silver(l) oxide; In pyridine; acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)80600-0

Reference yield:

allyl 6-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside (107823-72-3) → Acetic acid (2S,3R,4R,5S,6R)-4-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-4,5-diacetoxy-3-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-tetrahydro-pyran-2-yl ester (120567-17-1)

Guidance literature:

Multi-step reaction with 8 steps

1: 64 percent / SnCl₂, AgOTf, MS₄A / CH₂Cl₂; toluene

2: NaOMe, MeOH

3: 1) TsOH; 2) Amberlist 15 / 1) DMF; 2) MeOH

4: Ag₂O, KI / dimethylformamide

5: trifluoroacetic acid, H₂O, tetrahydrofuran

6: dimethylaminopropylamine / pyridine

7: PdCl₂/NaOAc / aq. acetic acid

With tetrahydrofuran; methanol; Amberlist 15; water; sodium methylate; sodium acetate; silver trifluoromethanesulfonate; toluene-4-sulfonic acid; 1-amino-3-(dimethylamino)propane; trifluoroacetic acid; potassium iodide; tin(ll) chloride; palladium dichloride; silver(l) oxide; In pyridine; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0040-4039(00)80600-0

Reference yield:

2-[(2R,3R,4R,5S,6R)-2-Allyloxy-6-benzyloxymethyl-4-hydroxy-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-isoindole-1,3-dione (120567-11-5) → Acetic acid (2S,3R,4R,5S,6R)-4-benzyloxy-6-benzyloxymethyl-5-((2S,3R,4S,5S,6R)-4,5-diacetoxy-3-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-tetrahydro-pyran-2-yl ester (120567-17-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 1) TsOH; 2) Amberlist 15 / 1) DMF; 2) MeOH

2: Ag₂O, KI / dimethylformamide

3: trifluoroacetic acid, H₂O, tetrahydrofuran

4: dimethylaminopropylamine / pyridine

5: PdCl₂/NaOAc / aq. acetic acid

With tetrahydrofuran; Amberlist 15; water; sodium acetate; toluene-4-sulfonic acid; 1-amino-3-(dimethylamino)propane; trifluoroacetic acid; potassium iodide; palladium dichloride; silver(l) oxide; In pyridine; acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)80600-0

upstream raw materials:

Acetic acid (2R,3S,4S,5R,6S)-3-acetoxy-6-[(2R,3S,4R,5R,6R)-6-allyloxy-4-benzyloxy-2-benzyloxymethyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-tetrahydro-pyran-3-yloxy]-5-benzyloxy-2-benzyloxymethyl-tetrahydro-pyran-4-yl ester

benzyl bromide

allyl 6-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside

2-[(2R,3R,4R,5S,6R)-2-Allyloxy-6-benzyloxymethyl-4-hydroxy-5-((3aS,4R,6S,7R,7aR)-7-hydroxy-4-hydroxymethyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yloxy)-tetrahydro-pyran-3-yl]-isoindole-1,3-dione

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