benzyl 5-amino-3-oxopent-4-enoate

Base Information

• Chemical Name: benzyl 5-amino-3-oxopent-4-enoate
• CAS No.: 108380-22-9
• Molecular Formula: C₁₂H₁₃NO₃
• Molecular Weight: 219.24
• Mol file: 108380-22-9.mol

Synonyms:

Chemical Property of benzyl 5-amino-3-oxopent-4-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 5-amino-3-oxopent-4-enoate

There total 4 articles about benzyl 5-amino-3-oxopent-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

2-azabicyclo<2.2.0>hexane-3,5-dione (97222-33-8) + benzyl alcohol (100-51-6,185532-71-2) → benzyl 5-amino-3-oxopent-4-enoate (108380-22-9)

Guidance literature:

In tetrahydrofuran; for 5h; Heating;

Reference yield:

5-benzyloxy-2-azabicyclo<2.2.0>hex-5-en-3-one (77149-75-8) → benzyl 5-amino-3-oxopent-4-enoate (108380-22-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / 10percent HCl; Dowex 1X₄ (base form) / tetrahydrofuran; H₂O; CH₂Cl₂

2: 20 percent / tetrahydrofuran / 5 h / Heating

With hydrogenchloride; Dowex 1X₄ (base form); In tetrahydrofuran; dichloromethane; water;

Reference yield:

5-methoxy-3-oxo-2-azabicyclo<2.2.0>hex-5-one (75608-94-5) → benzyl 5-amino-3-oxopent-4-enoate (108380-22-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / 10percent HCl; Dowex 1X₄ (base form) / tetrahydrofuran; H₂O; CH₂Cl₂ / 0.83 h / Ambient temperature

2: 20 percent / tetrahydrofuran / 5 h / Heating

With hydrogenchloride; Dowex 1X₄ (base form); In tetrahydrofuran; dichloromethane; water;

upstream raw materials:

2-azabicyclo<2.2.0>hexane-3,5-dione

benzyl alcohol

5-benzyloxy-2-azabicyclo<2.2.0>hex-5-en-3-one

5-methoxy-3-oxo-2-azabicyclo<2.2.0>hex-5-one

Refernces