1-Imidazolyl(4-methoxyphenyl)methanone

Base Information

• Chemical Name: 1-Imidazolyl(4-methoxyphenyl)methanone
• CAS No.: 10364-93-9
• Molecular Formula: C11H10N2O2
• Molecular Weight: 202.213
• DSSTox Substance ID: DTXSID90516160
• Nikkaji Number: J316.095E
• Wikidata: Q82377449
• Mol file: 10364-93-9.mol

Synonyms:1-imidazolyl(4-methoxyphenyl)methanone;10364-93-9;imidazol-1-yl-(4-methoxyphenyl)methanone;N-(p-methoxybenzoyl)imidazole;SCHEMBL11110140;DTXSID90516160;Imidazol-1-yl-(4-methoxy-phenyl)-methanone;(1H-Imidazol-1-yl)(4-methoxyphenyl)methanone

Chemical Property of 1-Imidazolyl(4-methoxyphenyl)methanone

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 202.074227566
• Heavy Atom Count: 15
• Complexity: 225

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)N2C=CN=C2

Technology Process of 1-Imidazolyl(4-methoxyphenyl)methanone

There total 4 articles about 1-Imidazolyl(4-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1H-imidazole (288-32-4) + 4-methoxy-benzoyl chloride (100-07-2) → 1-(4-methoxybenzoyl)-imidazole (10364-93-9)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 5h; Sealed tube; Inert atmosphere;

DOI:10.1002/anie.202107438

Reference yield: 17.0%

4-methoxybenzoyl isothiocyanate (16778-84-0) + 4',5'-Dihydro-1'H-[1,2']biimidazolyl (130838-42-5) → 1-(4-methoxybenzoyl)-imidazole (10364-93-9) + (2,4-Dithioxo-2,6,7,8-tetrahydro-imidazo[1,2-a][1,3,5]triazin-3-yl)-(4-methoxy-phenyl)-methanone

Guidance literature:

With pyridine; for 12h; Ambient temperature;

DOI:10.3987/COM-93-S75

Reference yield:

4-methoxybenzoic acid (100-09-4) + 1,1'-carbonyldiimidazole (530-62-1) → 1-(4-methoxybenzoyl)-imidazole (10364-93-9)

Guidance literature:

In tetrahydrofuran; for 0.333333h; Ambient temperature;

DOI:10.1021/jo00284a043

upstream raw materials:

1H-imidazole

4-methoxy-benzoyl chloride

4-methoxybenzoyl isothiocyanate

4',5'-Dihydro-1'H-[1,2']biimidazolyl

Downstream raw materials:

p-methoxybenzoyl p-nitrobenzoyl peroxide

1-(4-methoxyphenyl)-2,2-dimethyl-1-propanone

2'-O-anisoyladenosine

3'-O-anisoyladenosine