(1R,3aS,7aS)-7a-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[2-[(S)-5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-indene

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Chemical Name:(1R,3aS,7aS)-7a-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[2-[(S)-5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-indene
CAS No.:141245-55-8
Molecular Formula:C₄₁H₇₆O₄Si₂
Molecular Weight:689.223
Hs Code.:

(1R,3aS,7aS)-7a-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[2-[(S)-5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-indene

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Chemical Property of (1R,3aS,7aS)-7a-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[2-[(S)-5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-indene

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Technology Process of (1R,3aS,7aS)-7a-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[2-[(S)-5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-indene

There total 8 articles about (1R,3aS,7aS)-7a-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[2-[(S)-5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 141245-51-4
(1R,3aR,7aS)-7a-(tert-Butyl-dimethyl-silanyloxymethyl)-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-inden-4-one

: 138914-93-9
C₂₇H₃₆O₂PSi^(1-)

: 141245-55-8
(1R,3aS,7aS)-7a-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[2-[(S)-5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-indene

Guidance literature:: In tetrahydrofuran; for 1h; -78 deg C to r.t.;
DOI:10.1016/S0040-4039(00)91659-9

Reference yield:

: 135359-40-9
de-A,B-24-(methoxycarbonyl)-cholestan-8β-ol

: 141245-55-8
(1R,3aS,7aS)-7a-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[2-[(S)-5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-indene

Guidance literature:: Multi-step reaction with 8 steps

1: 62 percent / Pb(OAc)4 / benzene / 22 h / Heating

2: 95 percent / diethyl ether / -78 deg C to r.t.

3: 56 percent / NaIO₄, RuO₄*H₂O / CCl₄; H₂O; acetonitrile / 360 h / Ambient temperature

4: 98 percent / i-Pr₂NH, DMAP / CH₂Cl₂ / a) 0 deg C, 6 h, b) r.t., 12 h

5: 99 percent / diisobutylaluminum hydride (DIBAL-H) / tetrahydrofuran; toluene / a) -78 deg C, 15 min, b) -78 deg C to r.t.

6: 76 percent / imidazole / CH₂Cl₂; dimethylformamide / 1 h / Ambient temperature

7: 87 percent / pyridinium dichromate, PPTS / CH₂Cl₂ / a) 0 deg C, 1 h, b) r.t., 4 h

8: 87 percent / tetrahydrofuran / 1 h / -78 deg C to r.t.

With 1H-imidazole; lead(IV) acetate; dmap; sodium periodate; dipyridinium dichromate; ruthenium tetroxide; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; diisopropylamine; In tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; benzene;
DOI:10.1016/S0040-4039(00)91659-9

Reference yield:

: 141245-48-9
(R)-2-Methyl-6-(1S,2R,5R,6S)-11-oxa-tricyclo[4.3.2.0^1,5]undec-2-yl-heptan-2-ol

: 141245-55-8
(1R,3aS,7aS)-7a-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[2-[(S)-5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-indene

Guidance literature:: Multi-step reaction with 6 steps

1: 56 percent / NaIO₄, RuO₄*H₂O / CCl₄; H₂O; acetonitrile / 360 h / Ambient temperature

2: 98 percent / i-Pr₂NH, DMAP / CH₂Cl₂ / a) 0 deg C, 6 h, b) r.t., 12 h

3: 99 percent / diisobutylaluminum hydride (DIBAL-H) / tetrahydrofuran; toluene / a) -78 deg C, 15 min, b) -78 deg C to r.t.

4: 76 percent / imidazole / CH₂Cl₂; dimethylformamide / 1 h / Ambient temperature

5: 87 percent / pyridinium dichromate, PPTS / CH₂Cl₂ / a) 0 deg C, 1 h, b) r.t., 4 h

6: 87 percent / tetrahydrofuran / 1 h / -78 deg C to r.t.

With 1H-imidazole; dmap; sodium periodate; dipyridinium dichromate; ruthenium tetroxide; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; diisopropylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0040-4039(00)91659-9