135359-40-9

Usage

Chemical Properties

Pale Yellow Oil

Uses

An intermediate in the preparation of Calcifediol.

Upstream product

• 64190-52-9 (8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol 
• 116535-65-0 (1R,3aR,4S,7aR)-octahydro-1-[(S)-1-iodopropan-2-yl]-7a-methyl-1H-inden-4-ol 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 135359-41-0 de-A,B-24-(methoxycarbonyl)-cholestan-8-one 
• 141245-58-1 (R)-(1S,2R,5R,6S)-5-(11-Oxa-tricyclo[4.3.2.0^1,5]undec-2-yl)-hexanoic acid methyl ester 
• 70550-73-1 (1R,3aR,7aR)-1-[(2R)-6-hydroxy-6-methylhept-2-yl]-7a-methyloctahydroinden-4-one 
• 144848-24-8 25-[(triethylsilyl)oxy]de-A,B-cholestan-8-one 
• 78782-98-6 <26,27-2H6>-25-hydroxyvitamin D3 
• 19356-17-3 calcidiol 
• 135359-42-1 (R)-methyl 5-((1R,3aS,7aR,E)-4-((Z)-2-((S)-5-((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)hexanoate 
• 66774-84-3 de-A,B-25-hydroxycholestan-8β-ol 
• 141245-54-7 [(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-methoxymethoxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-inden-3a-ylmethoxy]-tert-butyl-dimethyl-silane 
• 141245-52-5 [(3R,3aS,7aS)-7-((3S,5R)-3,5-Bis-methoxymethoxy-2-methyl-cyclohex-1-enylethynyl)-3-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-1,2,3,4,5,7a-hexahydro-inden-3a-ylmethoxy]-tert-butyl-dimethyl-silane 
• 141245-53-6 [(3R,3aS,7aS)-7-[(Z)-2-((3S,5R)-3,5-Bis-methoxymethoxy-2-methyl-cyclohex-1-enyl)-vinyl]-3-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-1,2,3,4,5,7a-hexahydro-inden-3a-ylmethoxy]-tert-butyl-dimethyl-silane 
• 141245-55-8 (1R,3aS,7aS)-7a-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[2-[(S)-5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-octahydro-indene 
• 141245-44-5 1α,18,25-trihydroxyvitamin D₃ 
• 141245-45-6 18,25-dihydroxyvitamin D₃ 

Relevant academic research and scientific papers

A short, flexible route to vitamin D metabolites and their side chain analogues

A short, flexible approach to 25-functionalized vitamin D3 analogues including 26,27-hexadeutero-25 hydroxyvitamin D3 is described.

VITAMIN D3 DERIVATIVES AND PHARMACEUTICAL USE THEREOF

The present invention relates to vitamin D3 derivatives of the following formula, wherein each symbol has the same meaning as defined herein, and pharmaceutical or medical use thereof for treating metabolic disease, liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof.

An expeditious route to 1α,25-dihydroxyvitamin D3 and its analogues by an aqueous tandem palladium-catalyzed a-ring closure and suzuki coupling to the C/D unit

Chemical equation presented Daily vitamins: A mild, general, and highly stereoselective Pd0-catalyzed cascade to the triene system of the hoi mone 1α,25-dihydroxyvitamin D3 and six representative analogues is reported. The intramolecular cyclization of an enol-triflate (lower fragment) followed in situ by Suzuki Miyaura coupling with an alkenyl boronic ester (upper fragment, also efficiently prepared by Pd0-catalyzed coupling) in equimolar amounts under protic conditions is ideal for the preparation of small amounts of new vitamin D analogues for biological testing (see scheme).