(2E,4E,6E)-2,6-Dimethyl-octa-2,4,6-trienedioic acid 8-ethyl ester 1-((1S,2S)-2-formyl-2-hydroxy-1,3,3-trimethyl-cyclohexyl) ester

Base Information

• Chemical Name: (2E,4E,6E)-2,6-Dimethyl-octa-2,4,6-trienedioic acid 8-ethyl ester 1-((1S,2S)-2-formyl-2-hydroxy-1,3,3-trimethyl-cyclohexyl) ester
• CAS No.: 35482-66-7
• Molecular Formula: C₂₂H₃₂O₆
• Molecular Weight: 392.492
• Mol file: 35482-66-7.mol

Synonyms:

Chemical Property of (2E,4E,6E)-2,6-Dimethyl-octa-2,4,6-trienedioic acid 8-ethyl ester 1-((1S,2S)-2-formyl-2-hydroxy-1,3,3-trimethyl-cyclohexyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E,4E,6E)-2,6-Dimethyl-octa-2,4,6-trienedioic acid 8-ethyl ester 1-((1S,2S)-2-formyl-2-hydroxy-1,3,3-trimethyl-cyclohexyl) ester

There total 2 articles about (2E,4E,6E)-2,6-Dimethyl-octa-2,4,6-trienedioic acid 8-ethyl ester 1-((1S,2S)-2-formyl-2-hydroxy-1,3,3-trimethyl-cyclohexyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (all-E)-retinoate (3899-20-5,24519-09-3) → (2E,4E,6E)-2,6-Dimethyl-octa-2,4,6-trienedioic acid 8-ethyl ester 1-((1S,2S)-2-formyl-2-hydroxy-1,3,3-trimethyl-cyclohexyl) ester (35482-66-7)

Guidance literature:

With chromic acid;

DOI:10.1002/hlca.19710540808

Reference yield:

all-trans-retinoic-acid (302-79-4) → (2E,4E,6E)-2,6-Dimethyl-octa-2,4,6-trienedioic acid 8-ethyl ester 1-((1S,2S)-2-formyl-2-hydroxy-1,3,3-trimethyl-cyclohexyl) ester (35482-66-7)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃

2: H₂CrO₄

With chromic acid; potassium carbonate;

DOI:10.1002/hlca.19710540808

Reference yield:

(2E,4E,6E)-2,6-Dimethyl-octa-2,4,6-trienedioic acid 8-ethyl ester 1-((1S,2S)-2-formyl-2-hydroxy-1,3,3-trimethyl-cyclohexyl) ester (35482-66-7) → 1-Hydroxy-2,2-dimethyl-6-methylene-cyclohexanecarbaldehyde (35482-71-4)

Guidance literature:

at 200 ℃; under 0.6 Torr;

DOI:10.1002/hlca.19710540808

upstream raw materials:

ethyl (all-E)-retinoate

all-trans-retinoic-acid

Downstream raw materials:

1-Hydroxy-2,2-dimethyl-6-methylene-cyclohexanecarbaldehyde

(1S,2R)-2-Hydroxymethyl-1,3,3-trimethyl-cyclohexane-1,2-diol