Technology Process of 1-[9-chloro-1-(2,4-dichlorophenyl)-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazol-6-yl]propan-1-ol
There total 11 articles about 1-[9-chloro-1-(2,4-dichlorophenyl)-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazol-6-yl]propan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
tetrahydrofuran; diethyl ether;
at 0 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: tetrahydrofuran / 3 h / 0 - 20 °C
1.2: 14 h / 0 - 20 °C
2.1: triethylamine / methanol / 6 h / 50 °C
3.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 23 h / 20 °C
4.1: N-chloro-succinimide / acetonitrile / 17.5 h / 20 °C
5.1: tetrahydrofuran / 72 h / 20 °C
6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 3 h / 50 °C
7.1: pyridine; triethylamine / tetrahydrofuran / 13 h / 0 °C
8.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C
9.1: lithium borohydride / tetrahydrofuran / 16 h / 20 °C
10.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide; dichloromethane / 3 h / 20 °C
11.1: tetrahydrofuran; diethyl ether / 1 h / 0 °C
With
pyridine; N-chloro-succinimide; lithium borohydride; palladium 10% on activated carbon; hydrogen; sulfur trioxide pyridine complex; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2018.01.020
- Guidance literature:
-
Multi-step reaction with 10 steps
1: triethylamine / methanol / 6 h / 50 °C
2: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 23 h / 20 °C
3: N-chloro-succinimide / acetonitrile / 17.5 h / 20 °C
4: tetrahydrofuran / 72 h / 20 °C
5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 3 h / 50 °C
6: pyridine; triethylamine / tetrahydrofuran / 13 h / 0 °C
7: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C
8: lithium borohydride / tetrahydrofuran / 16 h / 20 °C
9: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide; dichloromethane / 3 h / 20 °C
10: tetrahydrofuran; diethyl ether / 1 h / 0 °C
With
pyridine; N-chloro-succinimide; lithium borohydride; palladium 10% on activated carbon; hydrogen; sulfur trioxide pyridine complex; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2018.01.020
![9-chloro-1-(2,4-dichlorophenyl)-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole-6-carbaldehyde](/Databaselist/images/loading.webp)
