Methanesulfonamide, N-(5-((1R)-2-(((1R)-1-(4-(difluoromethoxy)phenyl)-2-phenylethyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)-

Base Information

Chemical Name:Methanesulfonamide, N-(5-((1R)-2-(((1R)-1-(4-(difluoromethoxy)phenyl)-2-phenylethyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)-
CAS No.:170686-10-9
Molecular Formula:C₂₄H₂₆F₂N₂O₅S
Molecular Weight:492.544
Hs Code.:
UNII:FM0D5L3W03
Nikkaji Number:J1.642.167G
Wikidata:Q27278062
Pharos Ligand ID:Q15R231BGU56
ChEMBL ID:CHEMBL322862

Synonyms:BMS-196085;BMS196085

Suppliers and Price of Methanesulfonamide, N-(5-((1R)-2-(((1R)-1-(4-(difluoromethoxy)phenyl)-2-phenylethyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of Methanesulfonamide, N-(5-((1R)-2-(((1R)-1-(4-(difluoromethoxy)phenyl)-2-phenylethyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)-

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:11
Exact Mass:492.15304943
Heavy Atom Count:34
Complexity:694

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CS(=O)(=O)NC1=C(C=CC(=C1)C(CNC(CC2=CC=CC=C2)C3=CC=C(C=C3)OC(F)F)O)O
Isomeric SMILES:CS(=O)(=O)NC1=C(C=CC(=C1)[C@H](CN[C@H](CC2=CC=CC=C2)C3=CC=C(C=C3)OC(F)F)O)O

Technology Process of Methanesulfonamide, N-(5-((1R)-2-(((1R)-1-(4-(difluoromethoxy)phenyl)-2-phenylethyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)-

There total 7 articles about Methanesulfonamide, N-(5-((1R)-2-(((1R)-1-(4-(difluoromethoxy)phenyl)-2-phenylethyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(2-Benzyloxy-5-{(R)-2-[(R)-1-(4-difluoromethoxy-phenyl)-2-phenyl-ethylamino]-1-hydroxy-ethyl}-phenyl)-methanesulfonamide

: 170686-10-9
BMS-196085

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1016/S0960-894X(01)00629-1

Reference yield:

: 73960-07-3
4-difluoromethoxybenzaldehyde

: 170686-10-9
BMS-196085

Guidance literature:: Multi-step reaction with 7 steps

1: CHCl₃

2: CeCl₃ / tetrahydrofuran / -45 °C

3: Pb(OAc)4 / methanol

4: aq. HCl / methanol

5: diisopropylethylamine / tetrahydrofuran / 140 °C

6: aq. TFA / methanol

7: H₂ / Pd/C / methanol

With lead(IV) acetate; hydrogenchloride; cerium(III) chloride; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform;
DOI:10.1016/S0960-894X(01)00629-1

Reference yield:

: 948576-10-1,1184261-49-1
(R)-1-(4-Difluoromethoxy-phenyl)-2-phenyl-ethylamine

: 170686-10-9
BMS-196085

Guidance literature:: Multi-step reaction with 3 steps

1: diisopropylethylamine / tetrahydrofuran / 140 °C

2: aq. TFA / methanol

3: H₂ / Pd/C / methanol

With hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/S0960-894X(01)00629-1