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73960-07-3

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73960-07-3 Usage

Chemical Properties

light yellow liquid

Uses

4-(Difluoromethoxy)benzaldehyde may be used for the preparation of 4-(4-difluoro-methoxy-phen-yl)-1,2,3,4,5,6,7,8-octa-hydro-quinazoline-2,5-dione, via one-pot three-component reaction with cyclo-hexane-1,3-dione and urea.

General Description

4-(Difluoromethoxy)benzaldehyde is a p-difluoromethoxy substituted benzaldehyde.

Check Digit Verification of cas no

The CAS Registry Mumber 73960-07-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,9,6 and 0 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 73960-07:
(7*7)+(6*3)+(5*9)+(4*6)+(3*0)+(2*0)+(1*7)=143
143 % 10 = 3
So 73960-07-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H6F2O2/c9-8(10)12-7-3-1-6(5-11)2-4-7/h1-5,8H

73960-07-3 Well-known Company Product Price

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  • (Code)Product description
  • CAS number
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  • Detail
  • TCI America

  • (D4334)  4-(Difluoromethoxy)benzaldehyde  >98.0%(GC)

  • 73960-07-3

  • 1g

  • 250.00CNY

  • Detail
  • TCI America

  • (D4334)  4-(Difluoromethoxy)benzaldehyde  >98.0%(GC)

  • 73960-07-3

  • 5g

  • 880.00CNY

  • Detail
  • Alfa Aesar

  • (B20739)  4-(Difluoromethoxy)benzaldehyde, 97%   

  • 73960-07-3

  • 1g

  • 453.0CNY

  • Detail
  • Alfa Aesar

  • (B20739)  4-(Difluoromethoxy)benzaldehyde, 97%   

  • 73960-07-3

  • 2.5g

  • 835.0CNY

  • Detail
  • Alfa Aesar

  • (B20739)  4-(Difluoromethoxy)benzaldehyde, 97%   

  • 73960-07-3

  • 5g

  • 1419.0CNY

  • Detail
  • Alfa Aesar

  • (B20739)  4-(Difluoromethoxy)benzaldehyde, 97%   

  • 73960-07-3

  • 10g

  • 2412.0CNY

  • Detail
  • Aldrich

  • (470112)  4-(Difluoromethoxy)benzaldehyde  95%

  • 73960-07-3

  • 470112-1G

  • 482.04CNY

  • Detail
  • Aldrich

  • (470112)  4-(Difluoromethoxy)benzaldehyde  95%

  • 73960-07-3

  • 470112-5G

  • 1,900.08CNY

  • Detail

73960-07-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(Difluoromethoxy)benzaldehyde

1.2 Other means of identification

Product number -
Other names 4-(DIFLUOROMETHOXY)BENZALDEHYDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:73960-07-3 SDS

73960-07-3Relevant articles and documents

Difluoromethylation of Phenols and Thiophenols with the S-(Difluo-romethyl)sulfonium Salt: Reaction, Scope, and Mechanistic Study

Liu, Guo-Kai,Qin, Wen-Bing,Li, Xin,Lin, Li-Ting,Wong, Henry N. C.

, p. 15948 - 15957 (2019/11/16)

A facile and practical approach for the difluoromethylation of phenols and thiophenols was described. Making use of the recently developed bench-stable S-(difluoromethyl)sulfonium salt as the difluorocarbene precursor, a wide variety of diversely functionalized phenols and thiophenols were readily converted to their corresponding aryl difluoromethyl ethers in good to excellent yields in the presence of lithium hydroxide. Chemoselectivity of various O,S-nucleophiles toward difluorocarbene was systematically studied, suggesting the reactivity order ArS- > RS-, ArO- > ROH > RO-, ArSH, ArOH, RSH.

Decarboxylative Trifluoromethylating Reagent [Cu(O2CCF3)(phen)] and Difluorocarbene Precursor [Cu(phen)2][O2CCF2Cl]

Lin, Xiaoxi,Hou, Chuanqi,Li, Haohong,Weng, Zhiqiang

supporting information, p. 2075 - 2084 (2016/02/12)

This article describes the new economic decarboxylative trifluoromethylating reagent [Cu(phen)(O2CCF3)] (1; phen=1,10-phenanthroline) and the efficient difluorocarbene precursor [Cu(phen)2][O2CCF2Cl] (2). Treatment of copper tert-butoxide with phen and subsequent addition of trifluoroacetic acid or chlorodifluoroacetic acid afforded air-stable complexes 1 and 2, respectively, which were characterized by X-ray crystallography. The copper(I) ion in 1 is coordinated by a bidentate phen ligand, a monodentate trifluoroacetate group, and a molecule of CH3CN in a distorted tetrahedral coordination geometry. The molecular structure of 2 adopts an ionic form that consists of a [Cu(phen)2]+ cation and a chlorodifluoroacetate anion. Complex 1 reacted with a variety of aryl and heteroaryl halides to form trifluoromethyl (hetero)arenes in good yields. The corresponding Hammett plot exhibited a linear relationship and a reaction parameter (ρ)=+0.56±0.02, which indicated that the trifluoromethylation reaction proceeded via a nucleophilic reactive species. Complex 2 reacts with phenols to produce aryl difluoromethyl ethers in modest-to-excellent yields. Mechanistic investigations revealed that the difluoromethylation reaction proceeds by initial copper-mediated formation of difluorocarbene and subsequent concerted addition of difluorocarbene to the phenol to form a three-center transition state.

SYNTHESIS OF DIFLUOROMETHYL ETHERS AND SULFIDES

-

Paragraph 00166-00167, (2014/07/22)

The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone- depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.

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