(+/-)-2-[2-(diphenylphosphino)phenyl]-5,6-dihydro-4-phenyl-4H-1,3-oxazine

Base Information

• Chemical Name: (+/-)-2-[2-(diphenylphosphino)phenyl]-5,6-dihydro-4-phenyl-4H-1,3-oxazine
• CAS No.: 292140-03-5
• Molecular Formula: C₂₈H₂₄NOP
• Molecular Weight: 421.478
• Mol file: 292140-03-5.mol

Synonyms:

Chemical Property of (+/-)-2-[2-(diphenylphosphino)phenyl]-5,6-dihydro-4-phenyl-4H-1,3-oxazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-2-[2-(diphenylphosphino)phenyl]-5,6-dihydro-4-phenyl-4H-1,3-oxazine

There total 3 articles about (+/-)-2-[2-(diphenylphosphino)phenyl]-5,6-dihydro-4-phenyl-4H-1,3-oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

2-(diphenylphosphanyl)benzonitrile (34825-99-5) + 3-amino-3-phenyl-1-propanol (14593-04-5,82769-76-4) → (+/-)-2-[2-(diphenylphosphino)phenyl]-5,6-dihydro-4-phenyl-4H-1,3-oxazine (292140-03-5)

Guidance literature:

With zinc(II) chloride; In chlorobenzene; for 94h; Heating;

DOI:10.1002/1522-2675(20000607)83:6<1256::AID-HLCA1256>3.0.CO;2-5

Reference yield:

3-Amino-3-phenylpropionic acid (3646-50-2) → (+/-)-2-[2-(diphenylphosphino)phenyl]-5,6-dihydro-4-phenyl-4H-1,3-oxazine (292140-03-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / NaBH₄; cc. H₂SO₄ / tetrahydrofuran; diethyl ether / 0 - 20 °C

2: 28 percent / ZnCl₂ / chlorobenzene / 94 h / Heating

With sodium tetrahydroborate; sulfuric acid; zinc(II) chloride; In tetrahydrofuran; diethyl ether; chlorobenzene; 1: Reduction / 2: alcoholysis;

DOI:10.1002/1522-2675(20000607)83:6<1256::AID-HLCA1256>3.0.CO;2-5

Reference yield:

benzaldehyde (100-52-7) → (+/-)-2-[2-(diphenylphosphino)phenyl]-5,6-dihydro-4-phenyl-4H-1,3-oxazine (292140-03-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 34 percent / AcONH₄ / ethanol / 6 h / Heating

2: 89 percent / NaBH₄; cc. H₂SO₄ / tetrahydrofuran; diethyl ether / 0 - 20 °C

3: 28 percent / ZnCl₂ / chlorobenzene / 94 h / Heating

With sodium tetrahydroborate; sulfuric acid; ammonium acetate; zinc(II) chloride; In tetrahydrofuran; diethyl ether; ethanol; chlorobenzene; 1: Condensation / 2: Reduction / 3: alcoholysis;

DOI:10.1002/1522-2675(20000607)83:6<1256::AID-HLCA1256>3.0.CO;2-5

upstream raw materials:

2-(diphenylphosphanyl)benzonitrile

3-amino-3-phenyl-1-propanol

3-Amino-3-phenylpropionic acid

benzaldehyde

Refernces