3-({[(R)-3-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyryl)-5,5-dimethyl-thiazolidine-4-carbonyl]-amino}-methyl)-benzoic acid methyl ester

Base Information

Chemical Name:3-({[(R)-3-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyryl)-5,5-dimethyl-thiazolidine-4-carbonyl]-amino}-methyl)-benzoic acid methyl ester
CAS No.:858781-01-8
Molecular Formula:C₃₀H₃₉N₃O₇S
Molecular Weight:585.722
Hs Code.:

3-({[(R)-3-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyryl)-5,5-dimethyl-thiazolidine-4-carbonyl]-amino}-methyl)-benzoic acid methyl ester

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Chemical Property of 3-({[(R)-3-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyryl)-5,5-dimethyl-thiazolidine-4-carbonyl]-amino}-methyl)-benzoic acid methyl ester

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Technology Process of 3-({[(R)-3-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyryl)-5,5-dimethyl-thiazolidine-4-carbonyl]-amino}-methyl)-benzoic acid methyl ester

There total 3 articles about 3-({[(R)-3-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyryl)-5,5-dimethyl-thiazolidine-4-carbonyl]-amino}-methyl)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62023-65-8,76498-21-0,77171-41-6,82848-28-0,105181-72-4,116661-86-0
(2S,3S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenylbutanoic acid

: 858780-86-6
4-(3-methoxycarbonyl-benzylcarbamoyl)-5,5-dimethyl-thiazolidine-3-carboxylic acid tert-butyl ester

: 858781-01-8
3-({[(R)-3-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyryl)-5,5-dimethyl-thiazolidine-4-carbonyl]-amino}-methyl)-benzoic acid methyl ester

Guidance literature:: 4-(3-methoxycarbonyl-benzylcarbamoyl)-5,5-dimethyl-thiazolidine-3-carboxylic acid tert-butyl ester; With hydrogenchloride; methoxybenzene; In 1,4-dioxane; at 20 ℃; for 2h;

(2S,3S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenylbutanoic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; triethylamine; In water; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1002/ardp.200400882

Reference yield:

: 93071-65-9
3-methoxycarbonyl benzylamine

: 858781-01-8
3-({[(R)-3-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyryl)-5,5-dimethyl-thiazolidine-4-carbonyl]-amino}-methyl)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N; diphenylphosphochloridate / ethyl acetate / 1 h / 20 °C

1.2: Et₃N / ethyl acetate / 6 h / 20 °C

2.1: aq. HCl; anisole / dioxane / 2 h / 20 °C

2.2: 1-hydroxybenzotriazole; Et₃N; benzotriazol-1-yloxy-tris(dimethylamino)phosphonium PF₆ / dimethylformamide; H₂O / 20 °C

With hydrogenchloride; methoxybenzene; triethylamine; chlorophosphoric acid diphenyl ester; In 1,4-dioxane; ethyl acetate;
DOI:10.1002/ardp.200400882

Reference yield:

: 117918-23-7
(R)-3-tert-butoxycarbonyl-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid

: 858781-01-8
3-({[(R)-3-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyryl)-5,5-dimethyl-thiazolidine-4-carbonyl]-amino}-methyl)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N; diphenylphosphochloridate / ethyl acetate / 1 h / 20 °C

1.2: Et₃N / ethyl acetate / 6 h / 20 °C

2.1: aq. HCl; anisole / dioxane / 2 h / 20 °C

2.2: 1-hydroxybenzotriazole; Et₃N; benzotriazol-1-yloxy-tris(dimethylamino)phosphonium PF₆ / dimethylformamide; H₂O / 20 °C

With hydrogenchloride; methoxybenzene; triethylamine; chlorophosphoric acid diphenyl ester; In 1,4-dioxane; ethyl acetate;
DOI:10.1002/ardp.200400882