Technology Process of 4-aminomethyl-N-[1-(4-butyl-pyridin-2-yl)-2-cyclohexyl-ethyl]-benzamide
There total 10 articles about 4-aminomethyl-N-[1-(4-butyl-pyridin-2-yl)-2-cyclohexyl-ethyl]-benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: Isopropylbenzene; sodium amide / 150 °C
2: hydrogen bromide; bromine; sodium nitrite
3: n-butyllithium / -78 °C
5: hydrogen / palladium on activated charcoal
6: sodium periodate / tetrahydrofuran
7: dicyclohexyl-carbodiimide
8: trifluoroacetic acid
With
sodium periodate; n-butyllithium; Isopropylbenzene; hydrogen bromide; hydrogen; bromine; sodium amide; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium nitrite;
palladium on activated charcoal;
In
tetrahydrofuran;
1: amination / 2: Substitution / 3: Metallation / 3: Acylation / 4: Condensation / 5: Catalytic hydrogenation / 6: N-dealkylation / 7: Acylation / 8: acidolysis;
DOI:10.1016/S0960-894X(00)00482-0
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: diethyl ether
1.3: H3O+
2.1: potassium hydroxide; hydrazine
3.1: Isopropylbenzene; sodium amide / 150 °C
4.1: hydrogen bromide; bromine; sodium nitrite
5.1: n-butyllithium / -78 °C
7.1: hydrogen / palladium on activated charcoal
8.1: sodium periodate / tetrahydrofuran
9.1: dicyclohexyl-carbodiimide
10.1: trifluoroacetic acid
With
potassium hydroxide; sodium periodate; n-butyllithium; Isopropylbenzene; hydrogen bromide; hydrogen; bromine; sodium amide; dicyclohexyl-carbodiimide; trifluoroacetic acid; hydrazine; sodium nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether;
1.1: Metallation / 1.2: Grignard reaction / 1.3: Hydrolysis / 2.1: Reduction / 3.1: amination / 4.1: Substitution / 5.1: Metallation / 5.2: Acylation / 6.1: Condensation / 7.1: Catalytic hydrogenation / 8.1: N-dealkylation / 9.1: Acylation / 10.1: acidolysis;
DOI:10.1016/S0960-894X(00)00482-0
- Guidance literature:
-
Multi-step reaction with 9 steps
1: potassium hydroxide; hydrazine
2: Isopropylbenzene; sodium amide / 150 °C
3: hydrogen bromide; bromine; sodium nitrite
4: n-butyllithium / -78 °C
6: hydrogen / palladium on activated charcoal
7: sodium periodate / tetrahydrofuran
8: dicyclohexyl-carbodiimide
9: trifluoroacetic acid
With
potassium hydroxide; sodium periodate; n-butyllithium; Isopropylbenzene; hydrogen bromide; hydrogen; bromine; sodium amide; dicyclohexyl-carbodiimide; trifluoroacetic acid; hydrazine; sodium nitrite;
palladium on activated charcoal;
In
tetrahydrofuran;
1: Reduction / 2: amination / 3: Substitution / 4: Metallation / 4: Acylation / 5: Condensation / 6: Catalytic hydrogenation / 7: N-dealkylation / 8: Acylation / 9: acidolysis;
DOI:10.1016/S0960-894X(00)00482-0