5-methyl-2-(trifluoromethyl)-5,6-dihydrophenanthridine

Base Information

Chemical Name:5-methyl-2-(trifluoromethyl)-5,6-dihydrophenanthridine
CAS No.:1308866-38-7
Molecular Formula:C₁₅H₁₂F₃N
Molecular Weight:263.262
Hs Code.:

Synonyms:

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Chemical Property of 5-methyl-2-(trifluoromethyl)-5,6-dihydrophenanthridine

Chemical Property:

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Technology Process of 5-methyl-2-(trifluoromethyl)-5,6-dihydrophenanthridine

There total 5 articles about 5-methyl-2-(trifluoromethyl)-5,6-dihydrophenanthridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1308866-12-7
N-benzyl-2-iodo-N-methyl-4-(trifluoromethyl)aniline

: N-benzyl-N-methyl-4-(trifluoromethyl)benzenamine

: 1308866-38-7
5-methyl-2-(trifluoromethyl)-5,6-dihydrophenanthridine

Guidance literature:: With pyridine; potassium tert-butylate; at 20 - 160 ℃; for 0.183333h; regioselective reaction; Inert atmosphere; Microwave irradiation;
DOI:10.1021/ol201160s

Reference yield:

: 455-14-1
4-trifluoromethylphenylamine

: N-benzyl-N-methyl-4-(trifluoromethyl)benzenamine

: 1308866-38-7
5-methyl-2-(trifluoromethyl)-5,6-dihydrophenanthridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; dihydrogen peroxide; potassium iodide / methanol; water / 3 h / 60 °C / Inert atmosphere

2.1: acetic acid / methanol / 0.5 h / 20 °C / Inert atmosphere

3.1: sodium cyanoborohydride / methanol / 16 h / 0 - 20 °C / Inert atmosphere

4.1: acetic acid / water; acetonitrile / 0.5 h / 20 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

5.1: pyridine; potassium tert-butylate / 0.18 h / 20 - 160 °C / Inert atmosphere; Microwave irradiation

With pyridine; sulfuric acid; potassium tert-butylate; dihydrogen peroxide; sodium cyanoborohydride; acetic acid; potassium iodide; In methanol; water; acetonitrile;
DOI:10.1021/ol201160s

Reference yield:

: 163444-17-5
2-iodo-4-(trifluoromethyl)aniline

: N-benzyl-N-methyl-4-(trifluoromethyl)benzenamine

: 1308866-38-7
5-methyl-2-(trifluoromethyl)-5,6-dihydrophenanthridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / methanol / 0.5 h / 20 °C / Inert atmosphere

2.1: sodium cyanoborohydride / methanol / 16 h / 0 - 20 °C / Inert atmosphere

3.1: acetic acid / water; acetonitrile / 0.5 h / 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: pyridine; potassium tert-butylate / 0.18 h / 20 - 160 °C / Inert atmosphere; Microwave irradiation

With pyridine; potassium tert-butylate; sodium cyanoborohydride; acetic acid; In methanol; water; acetonitrile;
DOI:10.1021/ol201160s