(S)-2-Amino-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid {2-[2-(2,4-dichloro-phenoxy)-acetylamino]-ethyl}-amide

Base Information

• Chemical Name: (S)-2-Amino-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid {2-[2-(2,4-dichloro-phenoxy)-acetylamino]-ethyl}-amide
• CAS No.: 439286-56-3
• Molecular Formula: C₃₆H₄₀Cl₂N₄O₄
• Molecular Weight: 663.644
• Mol file: 439286-56-3.mol

Synonyms:

Chemical Property of (S)-2-Amino-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid {2-[2-(2,4-dichloro-phenoxy)-acetylamino]-ethyl}-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Amino-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid {2-[2-(2,4-dichloro-phenoxy)-acetylamino]-ethyl}-amide

There total 2 articles about (S)-2-Amino-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid {2-[2-(2,4-dichloro-phenoxy)-acetylamino]-ethyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2.4-Dichlor-phenoxyacetyl)-aethylendiamin (49808-81-3) + Fmoc-Lys(Mmt)-OH (159857-60-0) → (S)-2-Amino-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid {2-[2-(2,4-dichloro-phenoxy)-acetylamino]-ethyl}-amide (439286-56-3)

Guidance literature:

N-(2.4-Dichlor-phenoxyacetyl)-aethylendiamin; Fmoc-Lys(Mmt)-OH; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; for 24h;

With isopropylamine; In dichloromethane; for 0.5h; Further stages.;

DOI:10.1021/ac011051x

Reference yield:

2,4-Dichlorophenoxyacetic acid (94-75-7,89300-30-1) → (S)-2-Amino-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid {2-[2-(2,4-dichloro-phenoxy)-acetylamino]-ethyl}-amide (439286-56-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dicyclohexyl carbodiimide; hydroxybenzotriazole / 24 h

1.2: isopropylamine / CH₂Cl₂ / 0.5 h

With benzotriazol-1-ol; dicyclohexyl-carbodiimide;

DOI:10.1021/ac011051x

Reference yield:

fluoresceinyl 5-isothiocyanate (1173-43-9) + (S)-2-Amino-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid {2-[2-(2,4-dichloro-phenoxy)-acetylamino]-ethyl}-amide (439286-56-3) → N-(5-amino-1-{2-[2-(2,4-dichloro-phenoxy)-acetylamino]-ethylcarbamoyl}-pentyl)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-5-isothiocyanato-benzamide

Guidance literature:

fluoresceinyl 5-isothiocyanate; (S)-2-Amino-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid {2-[2-(2,4-dichloro-phenoxy)-acetylamino]-ethyl}-amide; With N-ethyl-N,N-diisopropylamine; In methanol;

With trifluoroacetic acid; In dichloromethane; for 0.333333h; Further stages.;

DOI:10.1021/ac011051x

upstream raw materials:

N-(2.4-Dichlor-phenoxyacetyl)-aethylendiamin

Fmoc-Lys(Mmt)-OH

2,4-Dichlorophenoxyacetic acid