(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(((4-Methoxyphenyl)diphenylmethyl)amino)hexanoic acid

Base Information

• Chemical Name: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(((4-Methoxyphenyl)diphenylmethyl)amino)hexanoic acid
• CAS No.: 159857-60-0
• Molecular Formula: C41H40N2O5
• Molecular Weight: 640.779
• Hs Code.: 2924297099
• DSSTox Substance ID: DTXSID40465311
• Wikidata: Q72478668
• Mol file: 159857-60-0.mol

Synonyms:159857-60-0;Fmoc-Lys(Mmt)-OH;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(((4-Methoxyphenyl)diphenylmethyl)amino)hexanoic acid;(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[[(4-methoxyphenyl)-diphenylmethyl]amino]hexanoic acid;L-Lysine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N6-[(4-methoxyphenyl)diphenylmethyl]-;fmoc-lys(4-methoxytrityl)-oh;N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-((4-methoxyphenyl)diphenylmethyl)-L-lysine;MFCD00270542;CTYHQVFFQRDJSN-LHEWISCISA-N;Fmoc-Lys(MMT);SCHEMBL19402725;DTXSID40465311;C41H40N2O5;AMY22679;STR09160;AKOS016843289;HY-W048704;AC-33836;BP-29700;PD197194;CS-0101019;F10666;N-alpha-Fmoc-N-epsilon-4-methoxytrityl-L-lysine;A883270;(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-6-{[(4-methoxyphenyl)diphenylmethyl]amino}hexanoic acid;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(((4-Methoxyphenyl)diphenylmethyl)amino)hexanoicacid;N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-4-methoxytrityl-L-lysine (Fmoc-L-Lys(Mmt)-OH);N~2~-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-N~6~-[(4-methoxyphenyl)(diphenyl)methyl]-L-lysine

Chemical Property of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(((4-Methoxyphenyl)diphenylmethyl)amino)hexanoic acid

Chemical Property:

• Boiling Point: 814.1±65.0 °C(Predicted)
• PKA: 3.83±0.21(Predicted)
• PSA: 96.89000
• Density: 1.210
• LogP: 8.52070
• Storage Temp.: Store at +2°C to +8°C.
• XLogP3: 5.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 15
• Exact Mass: 640.29372238
• Heavy Atom Count: 48
• Complexity: 961

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(((4-Methoxyphenyl)diphenylmethyl)amino)hexanoic acid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)NCCCCC(C(=O)O)NC(=O)OCC4C5=CC=CC=C5C6=CC=CC=C46
• Isomeric SMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)NCCCC[C@@H](C(=O)O)NC(=O)OCC4C5=CC=CC=C5C6=CC=CC=C46

Technology Process of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(((4-Methoxyphenyl)diphenylmethyl)amino)hexanoic acid

There total 2 articles about (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(((4-Methoxyphenyl)diphenylmethyl)amino)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-Lys-OH (105047-45-8) + mono-4-methoxytrityl chloride (14470-28-1) → Fmoc-Lys(Mmt)-OH (159857-60-0)

Guidance literature:

Fmoc-Lys-OH; With chloro-trimethyl-silane; In dichloromethane; at 20 - 50 ℃; for 1h; Heating / reflux;

mono-4-methoxytrityl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

C44H48N2O5Si → Fmoc-Lys(Mmt)-OH (159857-60-0)

Guidance literature:

In methanol; at 40 ℃; for 0.333333h; Yield given;

DOI:10.1016/S0040-4039(97)01158-1

Reference yield: 100.0%

Fmoc-Lys(Mmt)-OH (159857-60-0) → (S)-2-amino-6-((4-methoxyphenyl)diphenylmethyl-amino)hexanoic acid (159857-61-1)

Guidance literature:

With diethylamine; In N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1016/S0040-4039(97)01158-1

upstream raw materials:

Fmoc-Lys-OH

mono-4-methoxytrityl chloride

Downstream raw materials:

(S)-2-amino-6-((4-methoxyphenyl)diphenylmethyl-amino)hexanoic acid

Fmoc-Lys(Mmt)-aminobenzyl alcohol

(S)-2-Amino-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid {2-[2-(2,4-dichloro-phenoxy)-acetylamino]-ethyl}-amide

(S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid (4-hydroxymethyl-phenyl)-amide