2-(3,4-dichlorophenyl)-2-methylpent-4-enoic acid

Base Information

Chemical Name:2-(3,4-dichlorophenyl)-2-methylpent-4-enoic acid
CAS No.:619254-64-7
Molecular Formula:C₁₂H₁₂Cl₂O₂
Molecular Weight:259.132
Hs Code.:

Synonyms:

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Chemical Property of 2-(3,4-dichlorophenyl)-2-methylpent-4-enoic acid

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Technology Process of 2-(3,4-dichlorophenyl)-2-methylpent-4-enoic acid

There total 2 articles about 2-(3,4-dichlorophenyl)-2-methylpent-4-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5807-30-7
3,4-dichlorophenyl acetic acid

: 619254-64-7
2-(3,4-dichlorophenyl)-2-methylpent-4-enoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; pentane / 2 h / -25 °C / Inert atmosphere

1.2: 1.27 h / -25 - 20 °C / Inert atmosphere

2.1: thionyl chloride / 11.33 h / 20 °C / Inert atmosphere; Cooling with ice

3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 5 h / 0 - 20 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

4.1: lithium hydroxide; water / methanol / 10 h / Reflux

With thionyl chloride; water; sodium hydride; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil; pentane;
DOI:10.1021/ml400528y

Reference yield:

: 79333-48-5
2-(S)-(3,4-dichloro-phenyl)-4-pentenoic acid

: 619254-64-7
2-(3,4-dichlorophenyl)-2-methylpent-4-enoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 11.33 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 5 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: lithium hydroxide; water / methanol / 10 h / Reflux

With thionyl chloride; water; sodium hydride; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ml400528y

Reference yield:

: 619254-64-7
2-(3,4-dichlorophenyl)-2-methylpent-4-enoic acid

: 1563182-55-7
(S)-2-(3,4-dichlorophenyl)-2-methylpent-4-enoic acid 2-trimethylsilanylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: ethyl acetate / Resolution of racemate; Inert atmosphere

2: hydrogenchloride / ethyl acetate; water

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; pyridine / tetrahydrofuran / 18 h / 40 °C / Inert atmosphere

With pyridine; hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; water; ethyl acetate;
DOI:10.1021/ml400528y