tert-Butyl-[(2R,4aR,6S,7R,9aS)-6-(2,2-dibromo-vinyl)-2-phenyl-4a,6,7,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-7-yloxy]-diphenyl-silane

Base Information

Chemical Name:tert-Butyl-[(2R,4aR,6S,7R,9aS)-6-(2,2-dibromo-vinyl)-2-phenyl-4a,6,7,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-7-yloxy]-diphenyl-silane
CAS No.:1027925-80-9
Molecular Formula:C₃₂H₃₄Br₂O₄Si
Molecular Weight:670.513
Hs Code.:

tert-Butyl-[(2R,4aR,6S,7R,9aS)-6-(2,2-dibromo-vinyl)-2-phenyl-4a,6,7,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-7-yloxy]-diphenyl-silane

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Chemical Property of tert-Butyl-[(2R,4aR,6S,7R,9aS)-6-(2,2-dibromo-vinyl)-2-phenyl-4a,6,7,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-7-yloxy]-diphenyl-silane

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Technology Process of tert-Butyl-[(2R,4aR,6S,7R,9aS)-6-(2,2-dibromo-vinyl)-2-phenyl-4a,6,7,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-7-yloxy]-diphenyl-silane

There total 5 articles about tert-Butyl-[(2R,4aR,6S,7R,9aS)-6-(2,2-dibromo-vinyl)-2-phenyl-4a,6,7,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-7-yloxy]-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 558-13-4
carbon tetrabromide

: (2R,4aR,6R,7R,9aS)-7-(tert-Butyl-diphenyl-silanyloxy)-2-phenyl-4a,6,7,9a-tetrahydro-4H-1,3,5-trioxa-benzocycloheptene-6-carbaldehyde

: 1027925-80-9
tert-Butyl-[(2R,4aR,6S,7R,9aS)-6-(2,2-dibromo-vinyl)-2-phenyl-4a,6,7,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-7-yloxy]-diphenyl-silane

Guidance literature:: With triphenylphosphine; In dichloromethane; at -78 ℃; for 6h;
DOI:10.1055/s-2002-34904

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1027925-80-9
tert-Butyl-[(2R,4aR,6S,7R,9aS)-6-(2,2-dibromo-vinyl)-2-phenyl-4a,6,7,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-7-yloxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / 22.5 h / 70 °C

2: DIBALH / CH₂Cl₂ / 1 h / -78 °C

3: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.83 h / -78 - -47 °C

4: PPh₃ / CH₂Cl₂ / 6 h / -78 °C

With 1H-imidazole; oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; 3: Swern oxidation / 4: Wittig reaction;
DOI:10.1055/s-2002-34904

Reference yield:

: 475641-58-8
2,2-Dimethyl-propionic acid (2R,4aR,6S,7R,9aS)-7-hydroxy-2-phenyl-4a,6,7,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-6-ylmethyl ester

: 1027925-80-9
tert-Butyl-[(2R,4aR,6S,7R,9aS)-6-(2,2-dibromo-vinyl)-2-phenyl-4a,6,7,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-7-yloxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / 22.5 h / 70 °C

2: DIBALH / CH₂Cl₂ / 1 h / -78 °C

3: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.83 h / -78 - -47 °C

4: PPh₃ / CH₂Cl₂ / 6 h / -78 °C

With 1H-imidazole; oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; 3: Swern oxidation / 4: Wittig reaction;
DOI:10.1055/s-2002-34904