(1S,6S)-6-hydroxy-4-{{(4S,6R)-6-{(2R)-4-hydroxy-2-[(4-methoxybenzoyl)oxy]butyl}-2,2-dimethyl-1,3-dioxan-4-yl}methyl}cyclohept-3-en-1-yl 4-methoxybenzoate

Base Information

• Chemical Name: (1S,6S)-6-hydroxy-4-{{(4S,6R)-6-{(2R)-4-hydroxy-2-[(4-methoxybenzoyl)oxy]butyl}-2,2-dimethyl-1,3-dioxan-4-yl}methyl}cyclohept-3-en-1-yl 4-methoxybenzoate
• CAS No.: 753503-62-7
• Molecular Formula: C₃₄H₄₄O₁₀
• Molecular Weight: 612.717
• Mol file: 753503-62-7.mol

Synonyms:

Chemical Property of (1S,6S)-6-hydroxy-4-{{(4S,6R)-6-{(2R)-4-hydroxy-2-[(4-methoxybenzoyl)oxy]butyl}-2,2-dimethyl-1,3-dioxan-4-yl}methyl}cyclohept-3-en-1-yl 4-methoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,6S)-6-hydroxy-4-{{(4S,6R)-6-{(2R)-4-hydroxy-2-[(4-methoxybenzoyl)oxy]butyl}-2,2-dimethyl-1,3-dioxan-4-yl}methyl}cyclohept-3-en-1-yl 4-methoxybenzoate

There total 4 articles about (1S,6S)-6-hydroxy-4-{{(4S,6R)-6-{(2R)-4-hydroxy-2-[(4-methoxybenzoyl)oxy]butyl}-2,2-dimethyl-1,3-dioxan-4-yl}methyl}cyclohept-3-en-1-yl 4-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-Methylene-di[(1R,1'S,6R,6'S)-6-acetoxycyclohept-3-en-1-yl] bis(4-methoxybenzoate) (321146-15-0) → (1S,6S)-6-hydroxy-4-{{(4S,6R)-6-{(2R)-4-hydroxy-2-[(4-methoxybenzoyl)oxy]butyl}-2,2-dimethyl-1,3-dioxan-4-yl}methyl}cyclohept-3-en-1-yl 4-methoxybenzoate (753503-62-7)

Guidance literature:

Multi-step reaction with 5 steps

1: MeSO2NH2; ADmix(α) / H2O; 2-methyl-propan-2-ol; acetonitrile / 24 h

2: 97 percent / Mg(OMe)2 / methanol / 5 h

3: 99 percent / NaIO₄ / dioxane; H₂O

4: 70 percent / Me₄BH(OAc)3 / acetic acid / 24 h

5: 81 percent / pyridinium p-toluenesulfonate / acetone / 24 h

With sodium periodate; AD-mix-α; methanesulfonamide; Me₄BH(OAc)3; pyridinium p-toluenesulfonate; magnesium methanolate; In 1,4-dioxane; methanol; water; acetic acid; acetone; acetonitrile; tert-butyl alcohol;

DOI:10.1002/hlca.200490136

Reference yield:

(4S,6S)-tetrahydro-2-hydroxy-6-{3-{(4S,6S)-6-hydroxy-4-[(4-methoxybenzoyl)oxy]cyclohep-1-en-1-yl}-2-oxopropyl}-2H-pyran-4-yl 4-methoxybenzoate (753503-60-5) → (1S,6S)-6-hydroxy-4-{{(4S,6R)-6-{(2R)-4-hydroxy-2-[(4-methoxybenzoyl)oxy]butyl}-2,2-dimethyl-1,3-dioxan-4-yl}methyl}cyclohept-3-en-1-yl 4-methoxybenzoate (753503-62-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / Me₄BH(OAc)3 / acetic acid / 24 h

2: 81 percent / pyridinium p-toluenesulfonate / acetone / 24 h

With Me₄BH(OAc)3; pyridinium p-toluenesulfonate; In acetic acid; acetone;

DOI:10.1002/hlca.200490136

Reference yield:

(1S,6S)-6-(hydroxy)-{{(1R,2S,4S,6S)-1,2,6-trihydroxy-4-[(4-methoxybenzoyl)oxy]cycloheptyl}methyl}cyclohept-3-en-1-yl 4-methoxybenzoate (753503-58-1) → (1S,6S)-6-hydroxy-4-{{(4S,6R)-6-{(2R)-4-hydroxy-2-[(4-methoxybenzoyl)oxy]butyl}-2,2-dimethyl-1,3-dioxan-4-yl}methyl}cyclohept-3-en-1-yl 4-methoxybenzoate (753503-62-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / NaIO₄ / dioxane; H₂O

2: 70 percent / Me₄BH(OAc)3 / acetic acid / 24 h

3: 81 percent / pyridinium p-toluenesulfonate / acetone / 24 h

With sodium periodate; Me₄BH(OAc)3; pyridinium p-toluenesulfonate; In 1,4-dioxane; water; acetic acid; acetone;

DOI:10.1002/hlca.200490136

upstream raw materials:

4,4'-Methylene-di[(1R,1'S,6R,6'S)-6-acetoxycyclohept-3-en-1-yl] bis(4-methoxybenzoate)

(4S,6S)-tetrahydro-2-hydroxy-6-{3-{(4S,6S)-6-hydroxy-4-[(4-methoxybenzoyl)oxy]cyclohep-1-en-1-yl}-2-oxopropyl}-2H-pyran-4-yl 4-methoxybenzoate

(1S,6S)-6-(hydroxy)-{{(1R,2S,4S,6S)-1,2,6-trihydroxy-4-[(4-methoxybenzoyl)oxy]cycloheptyl}methyl}cyclohept-3-en-1-yl 4-methoxybenzoate

(1S,6S)-6-(acetyloxy)-{{(1R,2S,4S,6S)-6-(acetyloxy)-1,2-dihydroxy-4-[(4-methoxybenzoyl)oxy]cycloheptyl}methyl}cyclohept-3-en-1-yl 4-methoxybenzoate