C₂₁H₁₉NO₄S

Base Information

• Chemical Name: C₂₁H₁₉NO₄S
• CAS No.: 1422542-65-1
• Molecular Formula: C₂₁H₁₉NO₄S
• Molecular Weight: 381.452
• Mol file: 1422542-65-1.mol

Synonyms:

Chemical Property of C₂₁H₁₉NO₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₁₉NO₄S

There total 6 articles about C₂₁H₁₉NO₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

10H-phenothiazine (92-84-2) → C21H19NO4S (1422542-65-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 5 h / Reflux

1.2: 12 h / Reflux

2.1: sodium hydroxide / water / 20 - 30 °C

2.2: 2 h / 20 °C

3.1: dihydrogen peroxide; acetic acid / water-d2 / 3 h / 70 °C

4.1: thionyl chloride / toluene / 12 h / 80 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride / benzene / 2 h / 20 °C / Inert atmosphere; Schlenk technique

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 3 h / Reflux

7.1: hydrogen; palladium 10% on activated carbon / ethanol / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; tri-n-butyl-tin hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In tetrahydrofuran; ethanol; water; water-d2; toluene; acetonitrile; benzene; 6.1: |Wittig Olefination;

DOI:10.1016/j.ejmech.2012.10.051

Reference yield:

1,2-dihydropyrrolo[3,2,1-kl]-phenothiazin-1,2-dione (29939-43-3) → C21H19NO4S (1422542-65-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydroxide / water / 20 - 30 °C

1.2: 2 h / 20 °C

2.1: dihydrogen peroxide; acetic acid / water-d2 / 3 h / 70 °C

3.1: thionyl chloride / toluene / 12 h / 80 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride / benzene / 2 h / 20 °C / Inert atmosphere; Schlenk technique

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 3 h / Reflux

6.1: hydrogen; palladium 10% on activated carbon / ethanol / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; tri-n-butyl-tin hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In ethanol; water; water-d2; toluene; acetonitrile; benzene; 5.1: |Wittig Olefination;

DOI:10.1016/j.ejmech.2012.10.051

Reference yield:

10H-phenothiazine-1-carboxylic acid 5-oxide (1422542-48-0) → C21H19NO4S (1422542-65-1)

Guidance literature:

Multi-step reaction with 5 steps

1: dihydrogen peroxide; acetic acid / water-d2 / 3 h / 70 °C

2: thionyl chloride / toluene / 12 h / 80 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride / benzene / 2 h / 20 °C / Inert atmosphere; Schlenk technique

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 3 h / Reflux

5: hydrogen; palladium 10% on activated carbon / ethanol / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; tri-n-butyl-tin hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; water-d2; toluene; acetonitrile; benzene; 4: |Wittig Olefination;

DOI:10.1016/j.ejmech.2012.10.051

upstream raw materials:

10H-phenothiazine

1,2-dihydropyrrolo[3,2,1-kl]-phenothiazin-1,2-dione

10H-phenothiazine-1-carboxylic acid 5-oxide

10H-phenothiazine-1-carboxylic acid 5,5-dioxide