C₂₁H₂₁ClFN₃O₂

Base Information

Chemical Name:C₂₁H₂₁ClFN₃O₂
CAS No.:1338494-53-3
Molecular Formula:C₂₁H₂₁ClFN₃O₂
Molecular Weight:401.868
Hs Code.:

C<sub>21</sub>H<sub>21</sub>ClFN<sub>3</sub>O<sub>2</sub>

Synonyms:

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Chemical Property of C₂₁H₂₁ClFN₃O₂

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Technology Process of C₂₁H₂₁ClFN₃O₂

There total 6 articles about C₂₁H₂₁ClFN₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1338494-74-8
C₁₉H₂₀FN₃O

: 79-04-9
chloroacetyl chloride

: 1338494-53-3
C₂₁H₂₁ClFN₃O₂

Guidance literature:: In toluene; at 100 ℃; for 0.5h;
DOI:10.1021/ja2066972

Reference yield:

: 1338494-71-5
C₁₅H₁₃FN₂O₂

: 1338494-53-3
C₂₁H₂₁ClFN₃O₂

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / methanol / 2 h / 0 °C

2: lithium hydroxide / tetrahydrofuran; water / 2 h / 60 °C

3: N-ethyl-N,N-diisopropylamine; HATU / dimethyl sulfoxide

4: toluene / 0.5 h / 100 °C

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; toluene;
DOI:10.1021/ja2066972

Reference yield:

: 2739-98-2
ethyl 2-(pyridinyl-2)acetate

: 1338494-53-3
C₂₁H₂₁ClFN₃O₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: carbon tetrabromide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.5 h / -78 - 20 °C

2.1: triethylamine / tetrahydrofuran / 60 °C

2.2: 2 h / 70 °C

3.1: sodium tetrahydroborate / methanol / 2 h / 0 °C

4.1: lithium hydroxide / tetrahydrofuran; water / 2 h / 60 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / dimethyl sulfoxide

6.1: toluene / 0.5 h / 100 °C

With sodium tetrahydroborate; carbon tetrabromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; toluene;
DOI:10.1021/ja2066972