Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester

Base Information

• Chemical Name: Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester
• CAS No.: 162611-34-9
• Molecular Formula: C₄₇H₅₄N₇O₁₀P
• Molecular Weight: 907.96
• Mol file: 162611-34-9.mol

Synonyms:

Chemical Property of Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester

There total 3 articles about Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester (162611-34-9,162611-35-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / Et₃N / tetrahydrofuran / 2 h / Ambient temperature

2: Et₃N / tetrahydrofuran / 3 h / Ambient temperature

With triethylamine; In tetrahydrofuran;

DOI:10.1016/0040-4039(94)02403-X

Reference yield:

N,N-diisopropylphosphoramide dichloride (921-26-6) → Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester (162611-34-9,162611-35-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / Et₃N / tetrahydrofuran / 2 h / Ambient temperature

2: Et₃N / tetrahydrofuran / 3 h / Ambient temperature

With triethylamine; In tetrahydrofuran;

DOI:10.1016/0040-4039(94)02403-X

Reference yield:

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine (68892-41-1) + 4-nitrophenyl-N,N-diisopropylchlorophosphoramidite (162611-31-6) → Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester (162611-34-9,162611-35-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 3h; Yield given; Ambient temperature;

DOI:10.1016/0040-4039(94)02403-X

upstream raw materials:

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine

4-nitrophenyl-N,N-diisopropylchlorophosphoramidite

4-nitro-phenol

N,N-diisopropylphosphoramide dichloride