4-(Pyridin-2-ylmethyl)morpholine

Base Information

• Chemical Name: 4-(Pyridin-2-ylmethyl)morpholine
• CAS No.: 71897-59-1
• Molecular Formula: C10H14 N2 O
• Molecular Weight: 178.234
• European Community (EC) Number: 654-259-5
• NSC Number: 111161
• DSSTox Substance ID: DTXSID50296714
• Nikkaji Number: J3.483.996D
• Wikidata: Q82037429
• ChEMBL ID: CHEMBL1721156
• Mol file: 71897-59-1.mol

Synonyms:71897-59-1;2-(MORPHOLINOMETHYL)PYRIDINE;2-(Morpholinomethyl)-Pyridine;MLS002704262;4-(2-pyridinylmethyl)morpholine;4-(pyridin-2-ylmethyl)morpholine;NSC111161;pyridinylmethylmorpholine;SCHEMBL1054071;CHEMBL1721156;DTXSID50296714;LQPVTFUPUUWMIV-UHFFFAOYSA-N;2-[(4-morpholinyl)methyl]pyridine;AKOS002785229;NSC-111161;SMR001570965;FT-0766817;AB00087126-01;Z235575654

Chemical Property of 4-(Pyridin-2-ylmethyl)morpholine

Chemical Property:

• Vapor Pressure: 0.00988mmHg at 25°C
• Boiling Point: 264.1°C at 760 mmHg
• Flash Point: 113.5°C
• PSA: 25.36000
• Density: 1.113g/cm³
• LogP: 0.85170
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 178.110613074
• Heavy Atom Count: 13
• Complexity: 146

Purity/Quality:

2-(Morpholinomethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1CC2=CC=CC=N2

Technology Process of 4-(Pyridin-2-ylmethyl)morpholine

There total 7 articles about 4-(Pyridin-2-ylmethyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

morpholine (110-91-8,99108-56-2) + 2-chloromethylpyridine hydrochloride (6959-47-3) → 2-[(4-morpholinyl)methyl]pyridine (71897-59-1)

Guidance literature:

With potassium carbonate; sodium iodide; In acetonitrile; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02898

Reference yield: 73.0%

4-morpholinoacetonitrile (5807-02-3) + acetylene (74-86-2,25067-58-7) → 2-[(4-morpholinyl)methyl]pyridine (71897-59-1)

Guidance literature:

With cobaltocene; In tetrahydrofuran; at 155 ℃; for 2.5h; under 11400 Torr;

Reference yield:

2-(N,N-penta-3-oxa-1,5-diyl-carboxamido)-pyridine (112657-38-2) → 2-[(4-morpholinyl)methyl]pyridine (71897-59-1)

Guidance literature:

With 2-Picolinic acid; phenylsilane; zinc diacetate; In toluene; at 110 ℃; for 2h;

DOI:10.1039/d0sc02271c

upstream raw materials:

morpholine

4-morpholinoacetonitrile

acetylene

2-chloromethylpyridine hydrochloride

Downstream raw materials:

2-[(4-morpholinyl)methyl]piperidine

4-(phenyl(pyridin-2-yl)methyl)morpholine

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