1,8-Naphthyridine-3-carboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4- oxo-, monohydrochloride

Base Information

Chemical Name:1,8-Naphthyridine-3-carboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4- oxo-, monohydrochloride
CAS No.:104051-68-5
Molecular Formula:C20H17F3N4O3.ClH
Molecular Weight:454.836
Hs Code.:
Mol file:104051-68-5.mol

1,8-Naphthyridine-3-carboxylic acid,
1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-
oxo-, monohydrochloride

Synonyms:

Suppliers and Price of 1,8-Naphthyridine-3-carboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4- oxo-, monohydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,8-Naphthyridine-3-carboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4- oxo-, monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,8-Naphthyridine-3-carboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4- oxo-, monohydrochloride

There total 8 articles about 1,8-Naphthyridine-3-carboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4- oxo-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.2%

: 100492-07-7
1-(2,4-Difluoro-phenyl)-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester

: 104051-68-5
1-(2,4-Difluoro-phenyl)-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid; hydrochloride

Guidance literature:: With hydrogenchloride; at 110 ℃; for 24h;

Reference yield:

: 82671-06-5
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid

: 104051-68-5
1-(2,4-Difluoro-phenyl)-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / 2 h / 80 °C

2: 1.) n-BuLi, biquinoline / 1.) THF, hexane, from -30 deg C to -5 deg C, 2.) THF, hexane, RT, 1 h

3: 1.) Ac₂O / 1.) 130 deg C, 1 h, 2.) CH₂Cl₂, RT, 0.5 h

4: 86.5 percent / NaH / tetrahydrofuran / 1 h / Heating

5: 85.3 percent / pyridine / 3 h / Ambient temperature

6: 81.2 percent / 6N aq. HCl / 24 h / 110 °C

With pyridine; hydrogenchloride; n-butyllithium; thionyl chloride; biquinoline; acetic anhydride; sodium hydride; In tetrahydrofuran;

Reference yield:

: 96568-04-6
ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate

: 104051-68-5
1-(2,4-Difluoro-phenyl)-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Ac₂O / 1.) 130 deg C, 1 h, 2.) CH₂Cl₂, RT, 0.5 h

2: 86.5 percent / NaH / tetrahydrofuran / 1 h / Heating

3: 85.3 percent / pyridine / 3 h / Ambient temperature

4: 81.2 percent / 6N aq. HCl / 24 h / 110 °C

With pyridine; hydrogenchloride; acetic anhydride; sodium hydride; In tetrahydrofuran;