C₂₃H₃₃⁽¹⁸⁾FN₈O₅

Base Information

• Chemical Name: C₂₃H₃₃⁽¹⁸⁾FN₈O₅
• CAS No.: 1493775-79-3
• Molecular Formula: C₂₃H₃₃FN₈O₅
• Molecular Weight: 519.566
• Mol file: 1493775-79-3.mol

Synonyms:

Chemical Property of C₂₃H₃₃⁽¹⁸⁾FN₈O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₃₃⁽¹⁸⁾FN₈O₅

There total 5 articles about C₂₃H₃₃⁽¹⁸⁾FN₈O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H30N8O4*C4HF7O2 + N-succinimidyl 4-[18F]fluorobenzoate (141762-27-8) → C23H33(18)FN8O5 (1493775-79-3)

Guidance literature:

With sodium carbonate; In water; N,N-dimethyl-formamide; at 50 ℃; pH=9.5;

DOI:10.1021/ja408300e

Reference yield:

ethyl 4-[18F]fluorobenzoate (124915-09-9) → C23H33(18)FN8O5 (1493775-79-3)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrapropylammonium hydroxide / water; acetonitrile / 0.05 h / 120 °C

2: acetonitrile / 0.08 h / 90 °C

3: sodium carbonate / N,N-dimethyl-formamide; water / 50 °C / pH 9.5

With sodium carbonate; tetrapropylammonium hydroxide; In water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/ja408300e

Reference yield:

ethyl p-dimethyaminolbenzoate (10287-53-3) → C23H33(18)FN8O5 (1493775-79-3)

Guidance literature:

Multi-step reaction with 5 steps

1: diethyl ether

2: K[¹⁸F]F/K₂₂₂ / acetonitrile / 0.17 h / 90 °C

3: tetrapropylammonium hydroxide / water; acetonitrile / 0.05 h / 120 °C

4: acetonitrile / 0.08 h / 90 °C

5: sodium carbonate / N,N-dimethyl-formamide; water / 50 °C / pH 9.5

With sodium carbonate; tetrapropylammonium hydroxide; In diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/ja408300e

upstream raw materials:

ethyl 4-[18F]fluorobenzoate

tetrapropylammonium 4-[¹⁸F]fluorobenzoate

N-succinimidyl 4-[18F]fluorobenzoate

ethyl p-dimethyaminolbenzoate