(2E,4E,6E,8E)-9-[2,6-Dimethyl-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid ethyl ester

Base Information

Chemical Name:(2E,4E,6E,8E)-9-[2,6-Dimethyl-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid ethyl ester
CAS No.:127666-69-7
Molecular Formula:C₂₃H₂₅F₃N₂O₂
Molecular Weight:418.459
Hs Code.:

Synonyms:

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Chemical Property of (2E,4E,6E,8E)-9-[2,6-Dimethyl-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid ethyl ester

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Technology Process of (2E,4E,6E,8E)-9-[2,6-Dimethyl-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid ethyl ester

There total 8 articles about (2E,4E,6E,8E)-9-[2,6-Dimethyl-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5769-33-5
2,6-dimethyl-4-bromobenzaldehyde

: 127666-69-7
(2E,4E,6E,8E)-9-[2,6-Dimethyl-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / LiAlH₄ / tetrahydrofuran / 1 h / 4 °C

2: 85 percent / imidazole / dimethylformamide / 15 h / Ambient temperature

4: Ag₂O / diethyl ether

5: HCl / methanol

6: 1.2 g / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

7: 1) 1 M lithium bis(trimethylsilyl)amide / 1) THF, -78 deg C - 4 deg C, 2) THF, 20 min

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; pyridinium chlorochromate; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00303a038

Reference yield:

: 5757-66-4
4-bromo-2,6-dimethylbenzonitrile

: 127666-69-7
(2E,4E,6E,8E)-9-[2,6-Dimethyl-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 88 percent / diisobutylaluminum hydride (DIBAL) / benzene; hexane / 1 h / Ambient temperature

2: 88 percent / LiAlH₄ / tetrahydrofuran / 1 h / 4 °C

3: 85 percent / imidazole / dimethylformamide / 15 h / Ambient temperature

5: Ag₂O / diethyl ether

6: HCl / methanol

7: 1.2 g / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

8: 1) 1 M lithium bis(trimethylsilyl)amide / 1) THF, -78 deg C - 4 deg C, 2) THF, 20 min

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; diisobutylaluminium hydride; pyridinium chlorochromate; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00303a038

Reference yield:

: 17100-59-3
(4-bromo-2,6-dimethylphenyl)methanol

: 127666-69-7
(2E,4E,6E,8E)-9-[2,6-Dimethyl-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / imidazole / dimethylformamide / 15 h / Ambient temperature

3: Ag₂O / diethyl ether

4: HCl / methanol

5: 1.2 g / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

6: 1) 1 M lithium bis(trimethylsilyl)amide / 1) THF, -78 deg C - 4 deg C, 2) THF, 20 min

With 1H-imidazole; hydrogenchloride; pyridinium chlorochromate; silver(l) oxide; lithium hexamethyldisilazane; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00303a038