(2E,4E,6E,8E)-9-[2,6-Dimethyl-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-3,7-dimethyl-nona-2,4,6,8-tetraenal

Base Information

Chemical Name:(2E,4E,6E,8E)-9-[2,6-Dimethyl-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-3,7-dimethyl-nona-2,4,6,8-tetraenal
CAS No.:127685-64-7
Molecular Formula:C₂₁H₂₁F₃N₂O
Molecular Weight:374.406
Hs Code.:

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Chemical Property of (2E,4E,6E,8E)-9-[2,6-Dimethyl-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-3,7-dimethyl-nona-2,4,6,8-tetraenal

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Technology Process of (2E,4E,6E,8E)-9-[2,6-Dimethyl-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-3,7-dimethyl-nona-2,4,6,8-tetraenal

There total 9 articles about (2E,4E,6E,8E)-9-[2,6-Dimethyl-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-3,7-dimethyl-nona-2,4,6,8-tetraenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5769-33-5
2,6-dimethyl-4-bromobenzaldehyde

: 127685-64-7
(2E,4E,6E,8E)-9-[2,6-Dimethyl-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-3,7-dimethyl-nona-2,4,6,8-tetraenal

Guidance literature:: Multi-step reaction with 8 steps

1: 88 percent / LiAlH₄ / tetrahydrofuran / 1 h / 4 °C

2: 85 percent / imidazole / dimethylformamide / 15 h / Ambient temperature

4: Ag₂O / diethyl ether

5: HCl / methanol

6: 1.2 g / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

7: 1) 1 M lithium bis(trimethylsilyl)amide / 1) THF, -78 deg C - 4 deg C, 2) THF, 20 min

8: 1) diisobutylaluminum hydride, 2) MnO₂ / 1) ether, 2) CH₂Cl₂

With 1H-imidazole; hydrogenchloride; manganese(IV) oxide; lithium aluminium tetrahydride; diisobutylaluminium hydride; pyridinium chlorochromate; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00303a038

Reference yield:

: 5757-66-4
4-bromo-2,6-dimethylbenzonitrile

: 127685-64-7
(2E,4E,6E,8E)-9-[2,6-Dimethyl-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-3,7-dimethyl-nona-2,4,6,8-tetraenal

Guidance literature:: Multi-step reaction with 9 steps

1: 88 percent / diisobutylaluminum hydride (DIBAL) / benzene; hexane / 1 h / Ambient temperature

2: 88 percent / LiAlH₄ / tetrahydrofuran / 1 h / 4 °C

3: 85 percent / imidazole / dimethylformamide / 15 h / Ambient temperature

5: Ag₂O / diethyl ether

6: HCl / methanol

7: 1.2 g / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

8: 1) 1 M lithium bis(trimethylsilyl)amide / 1) THF, -78 deg C - 4 deg C, 2) THF, 20 min

9: 1) diisobutylaluminum hydride, 2) MnO₂ / 1) ether, 2) CH₂Cl₂

With 1H-imidazole; hydrogenchloride; manganese(IV) oxide; lithium aluminium tetrahydride; diisobutylaluminium hydride; pyridinium chlorochromate; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00303a038

Reference yield:

: 17100-59-3
(4-bromo-2,6-dimethylphenyl)methanol

: 127685-64-7
(2E,4E,6E,8E)-9-[2,6-Dimethyl-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-3,7-dimethyl-nona-2,4,6,8-tetraenal

Guidance literature:: Multi-step reaction with 7 steps

1: 85 percent / imidazole / dimethylformamide / 15 h / Ambient temperature

3: Ag₂O / diethyl ether

4: HCl / methanol

5: 1.2 g / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

6: 1) 1 M lithium bis(trimethylsilyl)amide / 1) THF, -78 deg C - 4 deg C, 2) THF, 20 min

7: 1) diisobutylaluminum hydride, 2) MnO₂ / 1) ether, 2) CH₂Cl₂

With 1H-imidazole; hydrogenchloride; manganese(IV) oxide; diisobutylaluminium hydride; pyridinium chlorochromate; silver(l) oxide; lithium hexamethyldisilazane; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00303a038