tert-butyl ((2R)-3-hydroxy-1-(((S)-1-(4-((E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl)phenoxy)-3-(1H-indol-3-yl)propan-2-yl)amino)-1-oxobutan-2-yl)carbamate

Base Information

Chemical Name:tert-butyl ((2R)-3-hydroxy-1-(((S)-1-(4-((E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl)phenoxy)-3-(1H-indol-3-yl)propan-2-yl)amino)-1-oxobutan-2-yl)carbamate
CAS No.:1598423-28-9
Molecular Formula:C₂₉H₃₆N₄O₇
Molecular Weight:552.627
Hs Code.:

tert-butyl ((2R)-3-hydroxy-1-(((S)-1-(4-((E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl)phenoxy)-3-(1H-indol-3-yl)propan-2-yl)amino)-1-oxobutan-2-yl)carbamate

Synonyms:

Suppliers and Price of tert-butyl ((2R)-3-hydroxy-1-(((S)-1-(4-((E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl)phenoxy)-3-(1H-indol-3-yl)propan-2-yl)amino)-1-oxobutan-2-yl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl ((2R)-3-hydroxy-1-(((S)-1-(4-((E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl)phenoxy)-3-(1H-indol-3-yl)propan-2-yl)amino)-1-oxobutan-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl ((2R)-3-hydroxy-1-(((S)-1-(4-((E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl)phenoxy)-3-(1H-indol-3-yl)propan-2-yl)amino)-1-oxobutan-2-yl)carbamate

There total 9 articles about tert-butyl ((2R)-3-hydroxy-1-(((S)-1-(4-((E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl)phenoxy)-3-(1H-indol-3-yl)propan-2-yl)amino)-1-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1598422-86-6
(E)-methyl 3-(4-((2S)-2-((2R)-2-((tert-butoxycarbonyl)amino)-3-hydroxybutanamido)-3-(1H-indol-3-yl)propoxy)phenyl)acrylate

: 1598423-28-9
tert-butyl ((2R)-3-hydroxy-1-(((S)-1-(4-((E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl)phenoxy)-3-(1H-indol-3-yl)propan-2-yl)amino)-1-oxobutan-2-yl)carbamate

Guidance literature:: With hydroxylamine hydrochloride; potassium hydroxide; In methanol;
DOI:10.1021/jm401877m

Reference yield:

: 7400-08-0,50940-26-6
p-Coumaric Acid

: 1598423-28-9
tert-butyl ((2R)-3-hydroxy-1-(((S)-1-(4-((E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl)phenoxy)-3-(1H-indol-3-yl)propan-2-yl)amino)-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetyl chloride / 5 h / 0 - 75 °C

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 0 °C

3.1: hydrogenchloride / ethyl acetate / 20 °C

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 0.5 h

4.2: 4 h

5.1: hydroxylamine hydrochloride; potassium hydroxide / methanol

With hydrogenchloride; hydroxylamine hydrochloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; acetyl chloride; triphenylphosphine; potassium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; 2.1: |Mitsunobu Displacement;
DOI:10.1021/jm401877m

Reference yield:

: 1526901-56-3
(S,E)-methyl 3-(4-(2-amino-3-(1H-indol-3-yl)propoxy)phenyl)acrylate hydrochloride

: 1598423-28-9
tert-butyl ((2R)-3-hydroxy-1-(((S)-1-(4-((E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl)phenoxy)-3-(1H-indol-3-yl)propan-2-yl)amino)-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 0.5 h

1.2: 4 h

2.1: hydroxylamine hydrochloride; potassium hydroxide / methanol

With hydroxylamine hydrochloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; potassium hydroxide; In methanol; dichloromethane;
DOI:10.1021/jm401877m