N-((7-(4-bromophenyl)-3-tosyl-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-d][1,4]diazepin-1-yl)methyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-((7-(4-bromophenyl)-3-tosyl-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-d][1,4]diazepin-1-yl)methyl)-4-methylbenzenesulfonamide
• CAS No.: 1623807-67-9
• Molecular Formula: C₂₉H₃₀BrN₃O₄S₂
• Molecular Weight: 628.611
• Mol file: 1623807-67-9.mol

Synonyms:

Chemical Property of N-((7-(4-bromophenyl)-3-tosyl-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-d][1,4]diazepin-1-yl)methyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((7-(4-bromophenyl)-3-tosyl-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-d][1,4]diazepin-1-yl)methyl)-4-methylbenzenesulfonamide

There total 5 articles about N-((7-(4-bromophenyl)-3-tosyl-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-d][1,4]diazepin-1-yl)methyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C29H28BrN3O4S2 → N-((7-(4-bromophenyl)-3-tosyl-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-d][1,4]diazepin-1-yl)methyl)-4-methylbenzenesulfonamide (1623807-67-9)

Guidance literature:

With sodium cyanoborohydride; In 1,2-dichloro-ethane; at 20 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201400881

Reference yield:

C12H12BrNO → N-((7-(4-bromophenyl)-3-tosyl-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-d][1,4]diazepin-1-yl)methyl)-4-methylbenzenesulfonamide (1623807-67-9)

Guidance literature:

Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 24 h / 0 - 20 °C / Schlenk technique

2: copper(I) thiophene-2-carboxylate / toluene / 20 °C / Schlenk technique

3: C₃₂H₆₄O₈Rh₂ / 1,2-dichloro-ethane / 2 h / 80 °C / Inert atmosphere; Schlenk technique

4: sodium cyanoborohydride / 1,2-dichloro-ethane / 12 h / 20 °C / Inert atmosphere; Schlenk technique

With copper(I) thiophene-2-carboxylate; di-isopropyl azodicarboxylate; C₃₂H₆₄O₈Rh₂; sodium cyanoborohydride; triphenylphosphine; In tetrahydrofuran; 1,2-dichloro-ethane; toluene;

DOI:10.1002/anie.201400881

Reference yield:

2-(4-bromophenyl)-1H-pyrrole (4995-11-3) → N-((7-(4-bromophenyl)-3-tosyl-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-d][1,4]diazepin-1-yl)methyl)-4-methylbenzenesulfonamide (1623807-67-9)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium hydroxide / dimethyl sulfoxide / 20 °C / Schlenk technique

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 24 h / 0 - 20 °C / Schlenk technique

3: copper(I) thiophene-2-carboxylate / toluene / 20 °C / Schlenk technique

4: C₃₂H₆₄O₈Rh₂ / 1,2-dichloro-ethane / 2 h / 80 °C / Inert atmosphere; Schlenk technique

5: sodium cyanoborohydride / 1,2-dichloro-ethane / 12 h / 20 °C / Inert atmosphere; Schlenk technique

With copper(I) thiophene-2-carboxylate; di-isopropyl azodicarboxylate; C₃₂H₆₄O₈Rh₂; sodium cyanoborohydride; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;

DOI:10.1002/anie.201400881

upstream raw materials:

2-(4-bromophenyl)-1H-pyrrole

N-(2-(2-(4-bromophenyl)-1H-pyrrol-1-yl)ethyl)-4-methyl-N-((1-tosyl-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide