4995-11-3

Usage

Structure

A derivative of pyrrole, a five-membered aromatic heterocycle with a nitrogen atom, with a bromine atom attached to the 2-position of the pyrrole ring and a phenyl group with a bromine atom at the 4-position attached to the pyrrole ring.

Usage

In organic synthesis and medicinal chemistry as a building block for the synthesis of various biologically active compounds.

Potential applications

In material science, as a starting material for the production of polymers and functional materials.

Upstream product

• 59862-55-4 p-bromoacetophenone oxime 
• 74-86-2 acetylene 
• 109-97-7 pyrrole 
• 5467-74-3 4-Bromophenylboronic acid 
• 673-40-5 4-bromobenzenediazonium tetrafluoroborate 
• 589-87-7 1,4-bromoiodobenzene 
• 1607800-84-9 tert-butyl 2-(4-bromophenyl)-1H-pyrrole-1-carboxylate 
• 184165-64-8 1-(4-bromophenyl)-3-buten-1-one 
• 106650-98-0 1-(4-bromophenyl)but-3-en-1-ol 
• 1122-91-4 4-bromo-benzaldehyde 
• 1616603-25-8 C₁₂H₁₂BrNO₂ 
• 65826-67-7 bis(4-bromophenyl)iodonium bromide 

Downstream Products

• 91735-78-3 2-(4-bromophenyl)-5-trifluoroacetylpyrrole 

Relevant academic research and scientific papers

Fabrication of Graphitic Carbon Nitride-Based Film: An Emerged Highly Efficient Catalyst for Direct C—H Arylation under Solar Light

Photoredox C—H bond formation can proceed in aerobic environment under solar light and has therefore become attractive. Nowadays, different types of expensive novel metal complexes and nanomaterials have been urbanized as photocatalysts for direct C—H bon

HEPATITIS C VIRUS INHIBITORS AND USES THEREOF IN PREPARATION OF DRUGS

A series of hepatitis C virus (HCV) inhibitors and compositions and applications thereof in the preparation of drugs for treating chronic HCV infection. Especially, a series of compounds that are used as NS5A inhibitors, and compositions and uses thereof in the preparations of drugs.

Copper-catalyzed 5-endo-trig cyclization of ketoxime carboxylates: A facile synthesis of 2-arylpyrroles

A novel and facile copper-catalyzed 5-endo-trig cyclization of ketoxime carboxylates for the synthesis of 2-arylpyrroles has been developed. The reaction tolerates a range of functional groups and is a practical procedure for rapid synthesis of 2-arylpyrroles in high yields under mild conditions. the Partner Organisations 2014.

Direct arylation of arene and N -heteroarenes with diaryliodonium salts without the use of transition metal catalyst

A novel and simple transition metal-free direct arylation of arene and N-heteroarenes with diaryliodonium salts has been developed. This cross-coupling reaction is promoted only by base and gives the desired products in moderate to good yields.

Iron-mediated direct suzuki-miyaura reaction: A new method for the ortho -arylation of pyrrole and pyridine

(Figure presented) The first example of an iron-mediated direct Suzuki-Miyaura reaction between N-heterocyclic compounds and arylboronic acids is described, and both electron-rich and electron-deficient heteroarenes can be successfully used for the coupling reaction.

PYRROLES FROM KETOXIMES AND ACETYLENE. 44. METHYL ARYL KETOXIMES WITH REACTIVE SUBSTITUENTS

The Trofinov reaction was extended to methyl aryl ketoximes with substituents in the benzene ring that are unstable with respect to the action of a strongly basic medium.The corresponding pyrroles and their 1-vinyl derivatives were obtained. 4-Nitroacetophenone oxime, from which only 2-phenyl- and 1-phenyl-2-phenylpyrrole were obtained, and 4-bromoacetophenone oxime, the reaction of which leads to the formation of 1-vinyl-2-(4-vinyloxyphenyl)pyrrole in addition to the principal 2-(4-bromophenyl)pyrrole, constituted exceptions.

PYRROLES FROM KETOXIMES AND ACETYLENE. XXVI. THE SYNTHESIS OF NEW 2-ARYLPYRROLES

New representatives of the 2-arylpyrrole series were obtained with yields of 36-90percent from the oximes of alkyl aryl ketones by the Trofimov reaction.When vinyl chloride was used instead of acetylene under the same conditions (potassium hydroxide-DMSO, 80-100 deg C), the pyrroles were obtained with yields of 2-7percent.