Technology Process of (1S,6S,7S,8aR)-1-(benzyloxy)-8,8-difluorooctahydroindolizine-6,7-diol
There total 12 articles about (1S,6S,7S,8aR)-1-(benzyloxy)-8,8-difluorooctahydroindolizine-6,7-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium penicillin V / methanol / 1 h
2.1: triethylamine; dmap / dichloromethane / 12 h / 0 - 20 °C
3.1: triphenylphosphine / tetrahydrofuran; water / 4 h / 80 °C
4.1: potassium carbonate / dichloromethane / 12 h / 20 °C
5.1: titanium(IV) isopropylate / toluene / 3 h / Reflux; Irradiation
5.2: 10 h / Reflux
6.1: osmium(VIII) oxide / water; acetone / 48 h / 20 °C
7.1: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Reflux
With
titanium(IV) isopropylate; dmap; osmium(VIII) oxide; dimethylsulfide borane complex; potassium carbonate; potassium penicillin V; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; water; acetone; toluene;
DOI:10.1016/j.cclet.2014.04.018
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: titanium(IV) isopropylate / toluene / 3 h / Reflux; Irradiation
1.2: 10 h / Reflux
2.1: osmium(VIII) oxide / water; acetone / 48 h / 20 °C
3.1: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Reflux
With
titanium(IV) isopropylate; osmium(VIII) oxide; dimethylsulfide borane complex;
In
tetrahydrofuran; water; acetone; toluene;
DOI:10.1016/j.cclet.2014.04.018
- Guidance literature:
-
Multi-step reaction with 2 steps
1: osmium(VIII) oxide / water; acetone / 48 h / 20 °C
2: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Reflux
With
osmium(VIII) oxide; dimethylsulfide borane complex;
In
tetrahydrofuran; water; acetone;
DOI:10.1016/j.cclet.2014.04.018
