2-[Benzyloxy-(2-benzyloxyamino-propionyl)-amino]-3-methyl-butyric acid 4-nitro-phenyl ester; hydrochloride

Base Information

Chemical Name:2-[Benzyloxy-(2-benzyloxyamino-propionyl)-amino]-3-methyl-butyric acid 4-nitro-phenyl ester; hydrochloride
CAS No.:77846-20-9
Molecular Formula:C₂₈H₃₁N₃O₇*ClH
Molecular Weight:558.031
Hs Code.:

Synonyms:

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Chemical Property of 2-[Benzyloxy-(2-benzyloxyamino-propionyl)-amino]-3-methyl-butyric acid 4-nitro-phenyl ester; hydrochloride

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Technology Process of 2-[Benzyloxy-(2-benzyloxyamino-propionyl)-amino]-3-methyl-butyric acid 4-nitro-phenyl ester; hydrochloride

There total 8 articles about 2-[Benzyloxy-(2-benzyloxyamino-propionyl)-amino]-3-methyl-butyric acid 4-nitro-phenyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 77846-20-9
2-[Benzyloxy-(2-benzyloxyamino-propionyl)-amino]-3-methyl-butyric acid 4-nitro-phenyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: H₂O / 2 h / Ambient temperature

2: 54 percent / Dicyclohexylcarbodiimide / ethyl acetate / 1.) 0 deg C, 45 min; 2.) room temp., 30 min

3: 87 percent / Me₃N*BH₃; HCl / diethyl ether / Ambient temperature

4: Pyridine / CH₂Cl₂ / 16 h / Ambient temperature

5: Me₃N*BH₃; HCl / dioxane / Ambient temperature

With pyridine; hydrogenchloride; trimethylamine-borane; dicyclohexyl-carbodiimide; In 1,4-dioxane; diethyl ether; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo00329a044

Reference yield:

: 77846-14-1
2-(Benzyloxy-{2-[(E)-benzyloxyimino]-propionyl}-amino)-3-methyl-butyric acid 4-nitro-phenyl ester

: 77846-20-9
2-[Benzyloxy-(2-benzyloxyamino-propionyl)-amino]-3-methyl-butyric acid 4-nitro-phenyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; trimethylamine-borane; In 1,4-dioxane; Ambient temperature;
DOI:10.1021/jo00329a044

Reference yield:

: 759-05-7
3-methyl-2-ketobutanoic acid

: 77846-20-9
2-[Benzyloxy-(2-benzyloxyamino-propionyl)-amino]-3-methyl-butyric acid 4-nitro-phenyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: H₂O / 2 h / Ambient temperature

2: 54 percent / Dicyclohexylcarbodiimide / ethyl acetate / 1.) 0 deg C, 45 min; 2.) room temp., 30 min

3: 87 percent / Me₃N*BH₃; HCl / diethyl ether / Ambient temperature

4: Pyridine / CH₂Cl₂ / 16 h / Ambient temperature

5: Me₃N*BH₃; HCl / dioxane / Ambient temperature

With pyridine; hydrogenchloride; trimethylamine-borane; dicyclohexyl-carbodiimide; In 1,4-dioxane; diethyl ether; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo00329a044