4''-O-(2-chlorophenethyl)carbamoyl erythromycin A

Base Information

• Chemical Name: 4''-O-(2-chlorophenethyl)carbamoyl erythromycin A
• CAS No.: 1253278-95-3
• Molecular Formula: C₄₆H₇₅ClN₂O₁₄
• Molecular Weight: 915.56
• Mol file: 1253278-95-3.mol

Synonyms:

Chemical Property of 4''-O-(2-chlorophenethyl)carbamoyl erythromycin A

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4''-O-(2-chlorophenethyl)carbamoyl erythromycin A

There total 4 articles about 4''-O-(2-chlorophenethyl)carbamoyl erythromycin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-O-acetyl-4''-O-acylimidazolyl erythromycin A (1253278-87-3) → 4''-O-(2-chlorophenethyl)carbamoyl erythromycin A (1253278-95-3)

Guidance literature:

Multi-step reaction with 2 steps

1: water / acetonitrile / 7 h / 50 °C

2: methanol / 12 h / 45 °C

With methanol; water; In acetonitrile;

DOI:10.1002/ardp.200900288

Reference yield:

erythromycin (114-07-8) → 4''-O-(2-chlorophenethyl)carbamoyl erythromycin A (1253278-95-3)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / ethyl acetate / 1 h / 20 °C

2: triethylamine / toluene / 36 h / 50 °C

3: water / acetonitrile / 7 h / 50 °C

4: methanol / 12 h / 45 °C

With pyridine; methanol; water; triethylamine; In ethyl acetate; toluene; acetonitrile;

DOI:10.1002/ardp.200900288

Reference yield:

C48H77ClN2O15 → 4''-O-(2-chlorophenethyl)carbamoyl erythromycin A (1253278-95-3)

Guidance literature:

With methanol; at 45 ℃; for 12h;

DOI:10.1002/ardp.200900288

upstream raw materials:

2'-O-acetyl-4''-O-acylimidazolyl erythromycin A

erythromycin

2'-O-acetylerythromycin A