Technology Process of (2S,6E,8E)-cyclofarnesa-4,6,8-triene-2,10,11-triol
There total 17 articles about (2S,6E,8E)-cyclofarnesa-4,6,8-triene-2,10,11-triol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
fluorosulphonic acid;
In
tetrahydrofuran; water;
at 20 ℃;
for 0.05h;
Overall yield = 65 %;
DOI:10.1039/c3ob41226a
- Guidance literature:
-
Multi-step reaction with 12 steps
1.1: zirconium(IV) chloride / dichloromethane / 0.17 h / 20 °C
2.1: triethylamine / dichloromethane / -40 °C
3.1: 2,6-dimethylpyridine / dichloromethane / 20 °C
4.1: sodium hydroxide / water; methanol / 20 °C
5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere
6.1: Dess-Martin periodane / dichloromethane / 0.25 h / 20 °C
7.1: pyrrolidine / diethyl ether / 20 °C
8.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 20 °C
8.2: 2 h / 0 - 20 °C
9.1: diisobutylaluminium hydride / toluene / 6 h / -20 - 20 °C
10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
11.1: diisobutylaluminium hydride / toluene / 6 h / -20 - 20 °C
12.1: fluorosulphonic acid / tetrahydrofuran; water / 0.05 h / 20 °C
With
pyrrolidine; 2,6-dimethylpyridine; n-butyllithium; tetrabutyl ammonium fluoride; fluorosulphonic acid; zirconium(IV) chloride; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; toluene;
8.1: |Horner-Wadsworth-Emmons Olefination / 8.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1039/c3ob41226a
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 20 °C
1.2: 2 h / 0 - 20 °C
2.1: diisobutylaluminium hydride / toluene / 6 h / -20 - 20 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
4.1: diisobutylaluminium hydride / toluene / 6 h / -20 - 20 °C
5.1: fluorosulphonic acid / tetrahydrofuran; water / 0.05 h / 20 °C
With
n-butyllithium; tetrabutyl ammonium fluoride; fluorosulphonic acid; diisobutylaluminium hydride;
In
tetrahydrofuran; hexane; water; toluene;
1.1: |Horner-Wadsworth-Emmons Olefination / 1.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1039/c3ob41226a
