2-fluoro-4-morpholinylpyridine

Base Information

• Chemical Name: 2-fluoro-4-morpholinylpyridine
• CAS No.: 1564591-74-7
• Molecular Formula: C₉H₁₁FN₂O
• Molecular Weight: 182.198
• Mol file: 1564591-74-7.mol

Synonyms:

Chemical Property of 2-fluoro-4-morpholinylpyridine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-fluoro-4-morpholinylpyridine

There total 3 articles about 2-fluoro-4-morpholinylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C9H13FN4O → 2-fluoro-4-morpholinylpyridine (1564591-74-7)

Guidance literature:

With copper(ll) sulfate pentahydrate; In water; at 110 ℃; for 1h;

DOI:10.1002/adsc.201500393

Reference yield:

2,4,6-trifluoropyridine (3512-17-2) → 2-fluoro-4-morpholinylpyridine (1564591-74-7)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

2: hydrazine hydrate / ethanol / 4 h / Reflux

3: copper(ll) sulfate pentahydrate / water / 1 h / 110 °C

With copper(ll) sulfate pentahydrate; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; water;

DOI:10.1002/adsc.201500393

Reference yield:

4-(2,6-difluoropyridin-4-yl)morpholine (1500084-07-0) → 2-fluoro-4-morpholinylpyridine (1564591-74-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 4 h / Reflux

2: copper(ll) sulfate pentahydrate / water / 1 h / 110 °C

With copper(ll) sulfate pentahydrate; hydrazine hydrate; In ethanol; water;

DOI:10.1002/adsc.201500393

upstream raw materials:

2,4,6-trifluoropyridine

4-(2,6-difluoropyridin-4-yl)morpholine