3512-17-2

Basic information

• Product Name: 2,4,6-TRIFLUOROPYRIDINE
• Synonyms: 2,4,6-TRIFLUOROPYRIDINE;2,4,6-Trifluoropyridine 98%;2,4,6-Trifluoropyridine98%;PYRIDINE,2,4,6-TRIFLUORO;2,4,6-trifluorpyridine
• CAS NO: 3512-17-2
• Molecular Formula: C₅H₂F₃N
• Molecular Weight: 133.07
• EINECS: -0
• Product Categories: Pyridine;Pyridines
• Mol File: 3512-17-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 102°C
• Flash Point: 17°C
• Appearance: /
• Density: 1,499 g/cm3
• Vapor Pressure: 17.2mmHg at 25°C
• Refractive Index: 1.412
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -7.23±0.10(Predicted)
• BRN: 1364338
• CAS DataBase Reference: 2,4,6-TRIFLUOROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-TRIFLUOROPYRIDINE(3512-17-2)
• EPA Substance Registry System: 2,4,6-TRIFLUOROPYRIDINE(3512-17-2)

Safety Data

• Hazard Codes: C,F,Xi
• Statements: 11-34-41-37/38
• Safety Statements: 16-26-36/37/39-45-39
• RIDADR: 1993
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 3512-17-2(Hazardous Substances Data)

Usage

Synthesis

Chambers converted 3,5-dichlorotrifluoropyridine into 2,4,6-trifluoropyridine over a palladium catalyst.

Uses

2,4,6-Trifluoropyridine is an intermediate in the synthesis of pharmaceutical goods.

InChI:InChI=1/C5H2F3N/c6-3-1-4(7)9-5(8)2-3/h1-2H

Upstream product

• 110-86-1 pyridine 
• 1333-74-0 hydrogen 
• 1737-93-5 3,5-dichloro-2,4,6-trifluoropyridine 

Downstream Products

• 1155847-15-6 3-chloro-5-[(2,6-difluoropyridin-4-yl)oxy]benzonitrile 
• 1369763-81-4 (1R,2S)-N-(2,6-difluoropyridin-4-yl)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxamide 
• 1369763-80-3 (1R,2S)-N-(4,6-difluoropyridin-2-yl)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxamide 
• 1564591-74-7 2-fluoro-4-morpholinylpyridine 
• 1071128-36-3 2-(4-methoxybenzylamino)-4-(3-(N-methyl-N-tert-butoxycarbonylamino)pyrrolidino)-6-fluoropyridine 
• 1071128-27-2 2-fluoro-4-(4-methylpiperazinyl)-6-(4-methoxybenzylamino)pyridine 
• 903513-58-6 4‐bromo‐2,6‐difluoropyridine 
• 1184172-35-7 2,6-difluoro-4-methoxypyridine 

Relevant articles and documents

Removal of fluorine from and introduction of fluorine into polyhalopyridines: An exercise in nucleophilic hetarenic substitution

Starting from six industrially available fluorinated pyridines, an expedient access to all three tetrafluoropyridines (2-4), all six trifluoropyridines (5-10), and the five non-commercial difluoropyridines (11-14 and 16) was developed. The methods employed for the selective removal of fluorine from polyfluoropyridines were the reduction by metals or complex hydrides and the site-selective replacement by hydrazine followed by dehydrogenation-dediazotation or dehydrochlorination-dediazotation. To introduce an extra fluorine atom, a suitable precursor was metalated and chlorinated before being subjected to a chlorine/ fluorine displacement process.

FLUORINATIONS WITH POTASSIUM TETRAFLUOROCOBALTATE(III) PART VII. FURTHER INVESTIGATIONS ON THE FLUORINATION OF PYRIDINE

The product from the fluorination of pyridine by KCoF4 at ca. 220 deg C contains eleven fluoropyridines, two fluoro-2-azahex-enes, three azahexadienes, and two fluoro-N-methylpyrrolidines, besides an azacyclohexa-1,3-diene.Four products were isolated from fluorination of pyridine by CoF3 at ca. 150 deg C, a 2-azahexene, two N-methylpyrrolidines, and 4H-nonafluoropiperidine.