(2S,4R)-tert-butyl 4-(benzyloxy)-2-(5-bromo-3-(3,5-difluorophenyl)-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(2S,4R)-tert-butyl 4-(benzyloxy)-2-(5-bromo-3-(3,5-difluorophenyl)-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)pyrrolidine-1-carboxylate
CAS No.:1403945-53-8
Molecular Formula:C₂₈H₂₇BrF₂N₄O₄
Molecular Weight:601.448
Hs Code.:

(2S,4R)-tert-butyl 4-(benzyloxy)-2-(5-bromo-3-(3,5-difluorophenyl)-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)pyrrolidine-1-carboxylate

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Chemical Property of (2S,4R)-tert-butyl 4-(benzyloxy)-2-(5-bromo-3-(3,5-difluorophenyl)-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)pyrrolidine-1-carboxylate

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Technology Process of (2S,4R)-tert-butyl 4-(benzyloxy)-2-(5-bromo-3-(3,5-difluorophenyl)-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)pyrrolidine-1-carboxylate

There total 4 articles about (2S,4R)-tert-butyl 4-(benzyloxy)-2-(5-bromo-3-(3,5-difluorophenyl)-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1403945-55-0
(2S,4R)-tert-butyl 4-(benzyloxy)-2-(3-bromo-2-(3,5-difluorophenylcarbamoyl)-1H-pyrrol-1-ylcarbamoyl)pyrrolidine-1-carboxylate

: 1403945-53-8
(2S,4R)-tert-butyl 4-(benzyloxy)-2-(5-bromo-3-(3,5-difluorophenyl)-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)pyrrolidine-1-carboxylate

Guidance literature:

Reference yield:

: 100-39-0
benzyl bromide

: 1403945-53-8
(2S,4R)-tert-butyl 4-(benzyloxy)-2-(5-bromo-3-(3,5-difluorophenyl)-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; hexanes / 0.17 h / Cooling with ice

1.2: 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

2.2: 0 °C

3.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; N,N-dimethyl-formamide / 48 h / 20 °C

With water; sodium hydride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; hexanes; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 136024-60-7
1-(tert-butyl) 2-methyl (2S,4R)-4-(benzyloxy)pyrrolidine-1,2-dicarboxylate

: 1403945-53-8
(2S,4R)-tert-butyl 4-(benzyloxy)-2-(5-bromo-3-(3,5-difluorophenyl)-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

1.2: 0 °C

2.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; N,N-dimethyl-formamide / 48 h / 20 °C

With water; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;