N-hydroxy-4-((2-(3-methoxybenzyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide TFA

Base Information

Chemical Name:N-hydroxy-4-((2-(3-methoxybenzyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide TFA
CAS No.:1354547-40-2
Molecular Formula:C₂HF₃O₂*C₂₇H₂₇N₃O₃
Molecular Weight:555.554
Hs Code.:

Synonyms:

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Chemical Property of N-hydroxy-4-((2-(3-methoxybenzyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide TFA

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Technology Process of N-hydroxy-4-((2-(3-methoxybenzyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide TFA

There total 4 articles about N-hydroxy-4-((2-(3-methoxybenzyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide TFA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₂₀N₂O

: 1354547-40-2
N-hydroxy-4-((2-(3-methoxybenzyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide TFA

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / 20 - 80 °C / Inert atmosphere

1.2: 2 h / 80 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium methylate / methanol; N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With hydroxylamine hydrochloride; potassium tert-butylate; sodium methylate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm200773h

Reference yield:

: 6208-60-2
2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

: 1354547-40-2
N-hydroxy-4-((2-(3-methoxybenzyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide TFA

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / acetonitrile / 20 - 60 °C / Inert atmosphere

1.2: 2 h / 60 °C / Inert atmosphere

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / 20 - 80 °C / Inert atmosphere

2.2: 2 h / 80 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium methylate / methanol; N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With hydroxylamine hydrochloride; potassium tert-butylate; sodium methylate; triethylamine; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm200773h

Reference yield:

: 6208-43-1
2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

: 1354547-40-2
N-hydroxy-4-((2-(3-methoxybenzyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide TFA

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol; water / 24 h / 70 °C / 760.05 Torr

2.1: triethylamine / acetonitrile / 20 - 60 °C / Inert atmosphere

2.2: 2 h / 60 °C / Inert atmosphere

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / 20 - 80 °C / Inert atmosphere

3.2: 2 h / 80 °C / Inert atmosphere

4.1: hydroxylamine hydrochloride; sodium methylate / methanol; N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With palladium 10% on activated carbon; hydroxylamine hydrochloride; potassium tert-butylate; hydrogen; sodium methylate; triethylamine; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm200773h