2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methylbenzo[d]thiazole-6-carboxylic acid

Base Information

Chemical Name:2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methylbenzo[d]thiazole-6-carboxylic acid
CAS No.:1383818-48-1
Molecular Formula:C₃₀H₂₈F₃N₃O₅S
Molecular Weight:599.631
Hs Code.:

2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methylbenzo[d]thiazole-6-carboxylic acid

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Chemical Property of 2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methylbenzo[d]thiazole-6-carboxylic acid

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Technology Process of 2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methylbenzo[d]thiazole-6-carboxylic acid

There total 11 articles about 2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methylbenzo[d]thiazole-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383818-47-0
methyl 2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methylbenzo[d]thiazole-6-carboxylate

: 1383818-48-1
2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methylbenzo[d]thiazole-6-carboxylic acid

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; water; at 70 ℃; for 1h;
DOI:10.1021/acs.jmedchem.7b00907

Reference yield:

: 225525-63-3
methyl 2-amino-4-methyl-1,3-benzothiazole-6-carboxylate

: 1383818-48-1
2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methylbenzo[d]thiazole-6-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: copper(I) bromide dimethylsulfide complex; tert.-butylnitrite / acetonitrile / 3.78 h / 0 - 45 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl acetamide / 1 h / 60 °C

3: potassium hydroxide / water; tetrahydrofuran; methanol / 1 h / 70 °C

With tert.-butylnitrite; copper(I) bromide dimethylsulfide complex; caesium carbonate; potassium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; acetonitrile; 1: |Sandmeyer Reaction;
DOI:10.1021/acs.jmedchem.7b00907

Reference yield:

: 18595-14-7
methyl 4-amino-3-methylbenzoate

: 1383818-48-1
2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methylbenzo[d]thiazole-6-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; bromine / 49 h / 0 - 30 °C

2: copper(I) bromide dimethylsulfide complex; tert.-butylnitrite / acetonitrile / 3.78 h / 0 - 45 °C / Inert atmosphere

3: caesium carbonate / N,N-dimethyl acetamide / 1 h / 60 °C

4: potassium hydroxide / water; tetrahydrofuran; methanol / 1 h / 70 °C

With tert.-butylnitrite; copper(I) bromide dimethylsulfide complex; bromine; caesium carbonate; acetic acid; potassium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; acetonitrile; 2: |Sandmeyer Reaction;
DOI:10.1021/acs.jmedchem.7b00907