18595-14-7

Basic information

• Product Name: Methyl 4-amino-3-methylbenzoate
• Synonyms: 4-Amino-3-methyl;Methyl 4-amino-3-methylbenzoate 98%;Methyl 4-Amion-3-Methylbenzoate;4-Amino-m-toluic acid methyl ester (COOCH3=1);Methyl 4-Aminol-3-Methylbenzoate;methyl-4-amino-3-methylbenzate;Methyl 4-amino-3-met;4-(Methoxycarbonyl)-2-methylaniline, 2-Amino-5-(methoxycarbonyl)toluene
• CAS NO: 18595-14-7
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.19
• Product Categories: FINE Chemical & INTERMEDIATES;Amines;blocks;Chemical intermediate for Telmisartan;Aromatic Esters;Esters;Phenyls & Phenyl-Het;Benzoic acid;(intermediate of telmisartan);Phenyls & Phenyl-Het;pharmaceutical intermediates
• Mol File: 18595-14-7.mol
• Article Data: 24

Chemical Properties

• Melting Point: 116 °C
• Boiling Point: 314.8 °C at 760 mmHg
• Flash Point: 167.5 °C
• Appearance: /Solid
• Density: 1.132 g/cm³
• Vapor Pressure: 0.000455mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMSO, Methanol
• PKA: 2.32±0.10(Predicted)
• CAS DataBase Reference: Methyl 4-amino-3-methylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-amino-3-methylbenzoate(18595-14-7)
• EPA Substance Registry System: Methyl 4-amino-3-methylbenzoate(18595-14-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-37/38-36-22
• Safety Statements: 26-37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 18595-14-7(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow crystal powder

Uses

Methyl 4-Amino-3-methylbenzoate is used in the synthesis of neuroprotective hydrazides used in the treatment of Alzheimer’s. It is also used in the research and development of diphenylamine-based retinoids.

InChI:InChI=1/C9H11NO2/c1-6-5-7(9(11)12-2)3-4-8(6)10/h3-5H,10H2,1-2H3

Upstream product

• 3113-71-1 3-methyl-4-nitrobenzoic acid 
• 186581-53-3 diazomethane 
• 2486-70-6 4-amino 3-methylbenzoic acid 
• 67-56-1 methanol 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 676-58-4 methylmagnesium chloride 
• 24078-21-5 methyl 3-methyl-4-nitrobenzoate 

Downstream Products

• 301533-59-5 methyl 4-(n-butyrylamino)-3-methylbenzoate 
• 180624-11-7 methyl 4-amino-3-iodo-5-methyl-benzoate 
• 933-67-5 7-methyl-1H-indole 
• 180624-25-3 7-methyl-1H-indole-5-carboxylic acid methyl ester 
• 180624-22-0 methyl 4-amino-5-methyl-3-[2-(trimethylsilyl)ethynyl]benzoate 
• 864296-21-9 4-(6-bromo-hexanoyl-amino)-3-methyl-benzoic acid methyl ester 
• 864296-60-6 4-([3-chloro-propanesulfonyl]-amino)-3-methyl-benzoic acid methyl ester 
• 3095-48-5 4-amino-3,5-dimethyl-benzoic acid methyl ester 
• 1210908-72-7 (E)-methyl 3-methyl-4-(5,5,5-trifluoro-4-oxopent-2-en-2-ylamino)benzoate 
• 1271212-15-7 C₃₅H₃₄Cl₂N₂O₄ 
• 1064195-49-8 N-[({1-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzyl]cyclopropyl}amino)carbonyl]-4-methylbenzenesulfonamide 
• 1064195-50-1 2-chloro-N-[({1-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzyl]cyclopropyl}amino)carbonyl]benzenesulfonamide 
• 1064195-64-7 C₃₃H₂₇ClF₆N₄O₆S 
• 1064195-51-2 N-[({1-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)-3-methylbenzyl]cyclopropyl}amino)carbonyl]-2-methylbenzenesulfonamide 

Relevant articles and documents

Hysteretic carbon dioxide sorption in a novel copper(ii)-indazole- carboxylate porous coordination polymer

The synthesis, structural and gas sorption studies of a porous Cu(ii) coordination polymer featuring 1H-indazole-5-carboxylic acid (H2L) are presented. [Cu(HL)2] is a thermally and hydrolytically robust 4-connected 3D coordination polymer of NbO topology and is replete with 1D channels that permit selective and hysteretic sorption of CO2. The Royal Society of Chemistry 2012.

Novel preparation method of antihypertensive drug telmisartan intermediate

The invention relates to an electric reduction preparation method of aminobenzoic acid represented by formula I and ester thereof. The preparation reaction of the method is shown in the description; and in the reaction formula, R is selected from hydrogen, a methyl group, an ethyl group, a benzyl group, a C3 or C4 straight-chain alkyl or branched-chain alkyl group, -NO2 is selected from 4-NO2 or 5-NO2, and Y is selected from H or 4-NHCOC3H7-n. The electroreduction preparation method of aminobenzoic acid and ester I thereof is characterized in that in a separated electrolytic cell, an acidic solution of nthe itrobenzoic acid and ester III thereof is taken as a catholyte; the voltage of a cathode working electrode relative to a reference electrode is 1.00-2.50 V; and an anolyte is an acidicsolution, the current density is 25.0-250.0 mA/cm, and the electrolysis temperature is 15-90 DEG C.

Gas-liquid flow hydrogenation of nitroarenes: Efficient access to a pharmaceutically relevant pyrrolobenzo[1,4]diazepine scaffold

Using a Tube-in-Tube device based on the amorphous Teflon AF-2400 fluoropolymer, a series of nitroarenes was hydrogenated to afford the corresponding aniline compounds. The system was then applied to the construction of a pyrrolobenzo[1,4]diazapene scaffold through a tandem hydrogenation-condensation-hydrogenation sequence.

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.