(E)-7-(3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-N-(1H-indazol-6-yl)-3-p-tolyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-8-carboxamide

Base Information

Chemical Name:(E)-7-(3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-N-(1H-indazol-6-yl)-3-p-tolyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-8-carboxamide
CAS No.:1430217-07-4
Molecular Formula:C₃₀H₂₃ClFN₁₁O₂
Molecular Weight:624.037
Hs Code.:

(E)-7-(3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-N-(1H-indazol-6-yl)-3-p-tolyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-8-carboxamide

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Chemical Property of (E)-7-(3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-N-(1H-indazol-6-yl)-3-p-tolyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-8-carboxamide

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Technology Process of (E)-7-(3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-N-(1H-indazol-6-yl)-3-p-tolyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-8-carboxamide

There total 8 articles about (E)-7-(3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-N-(1H-indazol-6-yl)-3-p-tolyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1430115-37-9
(E)-3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acrylic acid

: 1430115-41-5
tert-butyl 6-isocyano-1H-indazole-1-carboxylate

: 1430218-36-2
3-p-tolyl-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine

: 1430217-07-4
(E)-7-(3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-N-(1H-indazol-6-yl)-3-p-tolyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-8-carboxamide

Guidance literature:: With methanol; for 24h; Reflux;

Reference yield:

: 1094759-93-9
4-chloro-5-fluoro-2-iodo-phenylamine

: 1430217-07-4
(E)-7-(3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-N-(1H-indazol-6-yl)-3-p-tolyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-8-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide; acetic acid / 30 h

2: palladium diacetate; triethylamine / acetonitrile / 18 h / 85 °C / Inert atmosphere

3: methanol; sodium hydroxide / tetrahydrofuran / 2 h

4: methanol / 24 h / Reflux

With methanol; sodium azide; palladium diacetate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; acetonitrile;

Reference yield:

: 367-22-6
4-chloro-3-fluoroaniline

: 1430217-07-4
(E)-7-(3-(5-chloro-4-fluoro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-N-(1H-indazol-6-yl)-3-p-tolyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-8-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: iodine; sodium hydrogencarbonate / water / 18 h / 0 - 20 °C

2: sodium azide; acetic acid / 30 h

3: palladium diacetate; triethylamine / acetonitrile / 18 h / 85 °C / Inert atmosphere

4: methanol; sodium hydroxide / tetrahydrofuran / 2 h

5: methanol / 24 h / Reflux

With methanol; sodium azide; iodine; palladium diacetate; sodium hydrogencarbonate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; water; acetonitrile;