Technology Process of Ethyl-3,6-di-O-benzyl-2,4-didesoxy-2-methyl-4-methylen-β-DL-lyxo-hexopyranosid
There total 10 articles about Ethyl-3,6-di-O-benzyl-2,4-didesoxy-2-methyl-4-methylen-β-DL-lyxo-hexopyranosid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 99 percent / hydroquinone / 96 h / 6000480 Torr / Ambient temperature
2: 91 percent / K2CO3 / methanol / 20 h / Ambient temperature
3: 1.) NaH / 1.) DMF, 0 deg C, 1 h; 2.) 15 h
4: 98 percent / Raney-Nickel / tetrahydrofuran / 8 h / Ambient temperature
5: 1.) BH3*S(CH3)2; 2.) 30percent H2O2/10percent NaOH / 1.) THF, 15 h, -10 deg C; 2.) 0 deg C to room temp., 3 h
6: 74 percent / pyridinium chloro-chromate / CH2Cl2 / 144 h / Ambient temperature
7: 1.) 1.6M n-C4H9Li/n-hexane / 1.) THF, 45 min; 2.) THF, 19 h, room temp.
With
sodium hydroxide; n-butyllithium; hexane; dimethylsulfide borane complex; dihydrogen peroxide; nickel; sodium hydride; potassium carbonate; pyridinium chlorochromate;
hydroquinone;
In
tetrahydrofuran; methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 99 percent / hydroquinone / 96 h / 6000480 Torr / Ambient temperature
2: 91 percent / K2CO3 / methanol / 20 h / Ambient temperature
3: 1.) NaH / 1.) DMF, 0 deg C, 1 h; 2.) 15 h
4: 98 percent / Raney-Nickel / tetrahydrofuran / 8 h / Ambient temperature
5: 1.) BH3*S(CH3)2; 2.) 30percent H2O2/10percent NaOH / 1.) THF, 15 h, -10 deg C; 2.) 0 deg C to room temp., 3 h
6: 74 percent / pyridinium chloro-chromate / CH2Cl2 / 144 h / Ambient temperature
7: 1.) 1.6M n-C4H9Li/n-hexane / 1.) THF, 45 min; 2.) THF, 19 h, room temp.
With
sodium hydroxide; n-butyllithium; hexane; dimethylsulfide borane complex; dihydrogen peroxide; nickel; sodium hydride; potassium carbonate; pyridinium chlorochromate;
hydroquinone;
In
tetrahydrofuran; methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 35 percent / hydroquinone / CH2Cl2 / 72 h / 6000480 Torr / Ambient temperature
2: 96 percent / K2CO3 / methanol / 20 h / Ambient temperature
3: 1.) NaH / 1.) DMF, 0 deg C, 1 h; 2.) 15 h
4: 98 percent / Raney-Nickel / tetrahydrofuran / 8 h / Ambient temperature
5: 1.) BH3*S(CH3)2; 2.) 30percent H2O2/10percent NaOH / 1.) THF, 15 h, -10 deg C; 2.) 0 deg C to room temp., 3 h
6: 74 percent / pyridinium chloro-chromate / CH2Cl2 / 144 h / Ambient temperature
7: 1.) 1.6M n-C4H9Li/n-hexane / 1.) THF, 45 min; 2.) THF, 19 h, room temp.
With
sodium hydroxide; n-butyllithium; hexane; dimethylsulfide borane complex; dihydrogen peroxide; nickel; sodium hydride; potassium carbonate; pyridinium chlorochromate;
hydroquinone;
In
tetrahydrofuran; methanol; dichloromethane;
