Technology Process of 2-[5-((E)-2-cyanoethenesulfonyl)pyridin-2-yl]-N-cyclohexylisobutyramide
There total 3 articles about 2-[5-((E)-2-cyanoethenesulfonyl)pyridin-2-yl]-N-cyclohexylisobutyramide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C15H22N2O3S; 2-Chloroacrylonitrile;
With
acetic acid;
In
methanol; water;
at 20 ℃;
With
triethylamine;
for 1h;
DOI:10.1021/jm501437v
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
2.1: phenyllithium / toluene; tetrahydrofuran / 0.08 h / -80 °C / Inert atmosphere
2.2: 0.33 h
2.3: 0.17 h
3.1: acetic acid / water; methanol / 20 °C
3.2: 1 h
With
acetic acid; phenyllithium; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
2.1: phenyllithium / toluene; tetrahydrofuran / 0.08 h / -80 °C / Inert atmosphere
2.2: 0.33 h
2.3: 0.17 h
3.1: acetic acid / water; methanol / 20 °C
3.2: 1 h
With
acetic acid; phenyllithium; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;
