N-Benzyl-2-mercapto-thionicotinamide

Base Information

• Chemical Name: N-Benzyl-2-mercapto-thionicotinamide
• CAS No.: 154344-26-0
• Molecular Formula: C₁₃H₁₂N₂S₂
• Molecular Weight: 260.384

Synonyms:

Chemical Property of N-Benzyl-2-mercapto-thionicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Benzyl-2-mercapto-thionicotinamide

There total 22 articles about N-Benzyl-2-mercapto-thionicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-benzylisothiazolo<5,4-b>pyridine-3(2H)-thione (154344-32-8) → N-Benzyl-2-mercapto-thionicotinamide (154344-26-0)

Guidance literature:

With hydrogen sulfide; In ethanol; pH=7.4;

DOI:10.1016/S0014-827X(00)00084-7

Reference yield:

2-benzylisothiazolo<5,4-b>pyridin-3(2H)-one (91859-66-4) → N-Benzyl-2-mercapto-thionicotinamide (154344-26-0)

Guidance literature:

Multi-step reaction with 36 steps

1: Lawesson's reagent / toluene / 0.5 h / Heating

2: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

3: H₂S / ethanol / pH 7.4

4: 90 percent / Lawesson's reagent / toluene / 0.5 h / Heating

5: ethanol / Heating

6: I₂; NaHCO₃ / ethanol

7: Lawesson's reagent / toluene / 0.5 h / Heating

8: H₂S / ethanol / pH 7.4

9: I₂; NaHCO₃ / ethanol

10: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

11: H₂S / ethanol / pH 7.4

12: 90 percent / Lawesson's reagent / toluene / 0.5 h / Heating

13: ethanol / Heating

14: I₂; NaHCO₃ / ethanol

15: Lawesson's reagent / toluene / 0.5 h / Heating

16: H₂S / ethanol / pH 7.4

17: I₂; NaHCO₃ / ethanol

18: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

19: H₂S / ethanol / pH 7.4

20: 90 percent / Lawesson's reagent / toluene / 0.5 h / Heating

21: 77 percent / Lawesson's reagent / toluene / 3 h / Heating

22: ethanol / Heating

23: P₄S₁₀ / xylene / 2 h / Heating

24: ethanol / Heating

25: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

26: I₂; NaHCO₃ / ethanol

27: Lawesson's reagent / toluene / 0.5 h / Heating

28: H₂S / ethanol / pH 7.4

29: P₄S₁₀ / xylene / 2 h / Heating

30: ethanol / Heating

31: P₄S₁₀ / xylene / 2 h / Heating

32: ethanol / Heating

33: P₄S₁₀ / xylene / 2 h / Heating

34: ethanol / Heating

35: I₂; NaHCO₃ / ethanol

36: H₂S / ethanol / pH 7.4

With Lawessons reagent; tetraphosphorus decasulfide; hydrogen sulfide; mercury(II) diacetate; iodine; sodium hydrogencarbonate; acetic acid; In ethanol; chloroform; toluene; xylene;

DOI:10.1016/S0014-827X(00)00084-7

Reference yield:

N-(n-Butyl)-2-mercaptonicotinamid (65282-55-5) → N-Benzyl-2-mercapto-thionicotinamide (154344-26-0)

Guidance literature:

Multi-step reaction with 39 steps

1: 90 percent / Lawesson's reagent / toluene / 0.5 h / Heating

2: ethanol / Heating

3: I₂; NaHCO₃ / ethanol

4: Lawesson's reagent / toluene / 0.5 h / Heating

5: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

6: H₂S / ethanol / pH 7.4

7: 90 percent / Lawesson's reagent / toluene / 0.5 h / Heating

8: ethanol / Heating

9: I₂; NaHCO₃ / ethanol

10: Lawesson's reagent / toluene / 0.5 h / Heating

11: H₂S / ethanol / pH 7.4

12: I₂; NaHCO₃ / ethanol

13: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

14: H₂S / ethanol / pH 7.4

15: 90 percent / Lawesson's reagent / toluene / 0.5 h / Heating

16: ethanol / Heating

17: I₂; NaHCO₃ / ethanol

18: Lawesson's reagent / toluene / 0.5 h / Heating

19: H₂S / ethanol / pH 7.4

20: I₂; NaHCO₃ / ethanol

21: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

22: H₂S / ethanol / pH 7.4

23: 90 percent / Lawesson's reagent / toluene / 0.5 h / Heating

24: 77 percent / Lawesson's reagent / toluene / 3 h / Heating

25: ethanol / Heating

26: P₄S₁₀ / xylene / 2 h / Heating

27: ethanol / Heating

28: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

29: I₂; NaHCO₃ / ethanol

30: Lawesson's reagent / toluene / 0.5 h / Heating

31: H₂S / ethanol / pH 7.4

32: P₄S₁₀ / xylene / 2 h / Heating

33: ethanol / Heating

34: P₄S₁₀ / xylene / 2 h / Heating

35: ethanol / Heating

36: P₄S₁₀ / xylene / 2 h / Heating

37: ethanol / Heating

38: I₂; NaHCO₃ / ethanol

39: H₂S / ethanol / pH 7.4

With Lawessons reagent; tetraphosphorus decasulfide; hydrogen sulfide; mercury(II) diacetate; iodine; sodium hydrogencarbonate; acetic acid; In ethanol; chloroform; toluene; xylene;

DOI:10.1016/S0014-827X(00)00084-7

upstream raw materials:

2-benzylisothiazolo<5,4-b>pyridine-3(2H)-thione

benzylamine

3H-1,2-dithiolo<3,4-b>pyridine-3-thione

N-(n-Butyl)-2-mercaptonicotinamid

Downstream raw materials:

2-benzylisothiazolo<5,4-b>pyridine-3(2H)-thione

N-Benzyl-2-mercapto-nicotinamide

3H-1,2-dithiolo<3,4-b>pyridine-3-thione

2-Mercapto-N-(3-phenyl-propyl)-thionicotinamide

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