N-Benzyl-2-mercapto-nicotinamide

Base Information

• Chemical Name: N-Benzyl-2-mercapto-nicotinamide
• CAS No.: 91859-79-9
• Molecular Formula: C₁₃H₁₂N₂OS
• Molecular Weight: 244.317
• Mol file: 91859-79-9.mol

Synonyms:

Chemical Property of N-Benzyl-2-mercapto-nicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Benzyl-2-mercapto-nicotinamide

There total 26 articles about N-Benzyl-2-mercapto-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Benzyl-2-mercapto-thionicotinamide (154344-26-0) → N-Benzyl-2-mercapto-nicotinamide (91859-79-9)

Guidance literature:

With mercury(II) diacetate; acetic acid; In chloroform; at 20 ℃; for 0.5h;

DOI:10.1016/S0014-827X(00)00084-7

Reference yield:

N-(n-Butyl)-2-mercaptonicotinamid (65282-55-5) → N-Benzyl-2-mercapto-nicotinamide (91859-79-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 90 percent / Lawesson's reagent / toluene / 0.5 h / Heating

2: ethanol / Heating

3: I₂; NaHCO₃ / ethanol

4: Lawesson's reagent / toluene / 0.5 h / Heating

5: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

6: H₂S / ethanol / pH 7.4

With Lawessons reagent; hydrogen sulfide; mercury(II) diacetate; iodine; sodium hydrogencarbonate; acetic acid; In ethanol; chloroform; toluene;

DOI:10.1016/S0014-827X(00)00084-7

Reference yield:

2-propylisothiazolo<5,4-b>pyridine-3(2H)-thione (154344-50-0) → N-Benzyl-2-mercapto-nicotinamide (91859-79-9)

Guidance literature:

Multi-step reaction with 34 steps

1: H₂S / ethanol / pH 7.4

2: I₂; NaHCO₃ / ethanol

3: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

4: H₂S / ethanol / pH 7.4

5: 90 percent / Lawesson's reagent / toluene / 0.5 h / Heating

6: ethanol / Heating

7: I₂; NaHCO₃ / ethanol

8: Lawesson's reagent / toluene / 0.5 h / Heating

9: H₂S / ethanol / pH 7.4

10: I₂; NaHCO₃ / ethanol

11: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

12: H₂S / ethanol / pH 7.4

13: 90 percent / Lawesson's reagent / toluene / 0.5 h / Heating

14: 77 percent / Lawesson's reagent / toluene / 3 h / Heating

15: ethanol / Heating

16: P₄S₁₀ / xylene / 2 h / Heating

17: ethanol / Heating

18: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

19: I₂; NaHCO₃ / ethanol

20: Lawesson's reagent / toluene / 0.5 h / Heating

21: H₂S / ethanol / pH 7.4

22: P₄S₁₀ / xylene / 2 h / Heating

23: ethanol / Heating

24: P₄S₁₀ / xylene / 2 h / Heating

25: ethanol / Heating

26: P₄S₁₀ / xylene / 2 h / Heating

27: ethanol / Heating

28: I₂; NaHCO₃ / ethanol

29: H₂S / ethanol / pH 7.4

30: P₄S₁₀ / xylene / 2 h / Heating

31: ethanol / Heating

32: I₂; NaHCO₃ / ethanol

33: H₂S / ethanol / pH 7.4

34: Hg(OAc)2; AcOH / CHCl₃ / 0.5 h / 20 °C

With Lawessons reagent; tetraphosphorus decasulfide; hydrogen sulfide; mercury(II) diacetate; iodine; sodium hydrogencarbonate; acetic acid; In ethanol; chloroform; toluene; xylene;

DOI:10.1016/S0014-827X(00)00084-7

upstream raw materials:

N-Benzyl-2-mercapto-thionicotinamide

benzylamine

1,2-dithiolo<5,4-b>pyridin-3-one

N-(n-Butyl)-2-mercaptonicotinamid

Downstream raw materials:

2-benzylisothiazolo<5,4-b>pyridin-3(2H)-one

1,2-dithiolo<5,4-b>pyridin-3-one

3H-1,2-dithiolo<3,4-b>pyridine-3-thione

2-mercapto-N-(3-phenyl-propyl)-nicotinamide